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Tbio
FBXO2
F-box only protein 2

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354287
  • ENSP00000346240
  • ENSG00000116661

Symbol
  • FBX2
  • FBG1
  • FBX2
  • Fbs1
  • OCP1
  • NFB42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
PubMedID
0.73
histone modification site profile
0.69
small molecule perturbation
0.63
virus perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.59   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.59   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
1
1
27.3
hip bone size
1
1
1
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
27.3
hip bone size
1
9.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 2
VGNC:1238
457951
Macaque
F-box protein 2
722738
Mouse
MGI:2446216
230904
Rat
RGD:621751
85273
Dog
F-box protein 2
VGNC:49675
478231
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 2
Macaque
F-box protein 2
Mouse
Rat
Dog
F-box protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UK22-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (364)
1 – 10 of 364
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.995443671
p_ni:  0.004556329
Score:  0.99
Data Source:  BioPlex,STRINGDB
NTM
Tbio
Novelty:  0.01659865
p_int:  0.995153059
p_ni:  0.004846918
p_wrong:  2.3e-8
Score:  0.668
Data Source:  BioPlex,STRINGDB
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.994078605
p_ni:  0.005921361
p_wrong:  3.4e-8
Data Source:  BioPlex
LAG3
Tbio
Novelty:  0.00187736
p_int:  0.989571326
p_ni:  0.010428646
p_wrong:  2.8e-8
Data Source:  BioPlex
CDHR2
Tbio
Novelty:  0.09806551
p_int:  0.985337731
p_ni:  0.014662269
p_wrong:  1e-9
Data Source:  BioPlex
BOC
Tbio
Novelty:  0.10938194
p_int:  0.978513561
p_ni:  0.021486439
Data Source:  BioPlex
RNASET2
Tbio
Family:  Enzyme
Novelty:  0.01939252
p_int:  0.976842145
p_ni:  0.023157684
p_wrong:  1.71e-7
Score:  0.241
Data Source:  BioPlex,STRINGDB
GIF
Tbio
Novelty:  0.00508343
p_int:  0.975502876
p_ni:  0.024495792
p_wrong:  0.000001332
Score:  0.214
Data Source:  BioPlex,STRINGDB
AMIGO3
Tdark
Novelty:  7.6744186
p_int:  0.966122855
p_ni:  0.033877133
p_wrong:  1.1e-8
Data Source:  BioPlex
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.961330671
p_ni:  0.038669318
p_wrong:  1.1e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  74.59

PubMed score by year
PubTator Score  29.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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