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Tclin
KCND3
Potassium voltage-gated channel subfamily D member 3

Protein Summary
Description
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302127
  • ENSP00000306923
  • ENSG00000171385
  • ENST00000315987
  • ENSP00000319591
  • ENST00000369697
  • ENSP00000358711

Symbol
  • KV4.3
  • SCA19
  • SCA22
  • BRGDA9
  • KCND3L
  • KCND3S
  • KSHIVB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.94
disease perturbation
0.68
PubMedID
0.64
transcription factor
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.34   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.34   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (184)
KCNIP1
Tbio
Family:  IC
Novelty:  0.01790042
Score:  0.998
Data Source:  Reactome,STRINGDB
KCNIP2
Tbio
Family:  IC
Novelty:  0.01123517
Score:  0.998
Data Source:  Reactome,STRINGDB
KCNIP4
Tbio
Family:  IC
Novelty:  0.00973829
Score:  0.983
Data Source:  Reactome,STRINGDB
KCNIP3
Tbio
Family:  IC
Novelty:  0.01371555
Score:  0.978
Data Source:  Reactome,STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.965
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.962
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.943
Data Source:  STRINGDB
KCNH2
Tclin
Family:  IC
Novelty:  0.00041611
Score:  0.879
Data Source:  STRINGDB
NCS1
Tbio
Novelty:  0.0051468
Score:  0.85
Data Source:  STRINGDB
DPP6
Tbio
Family:  Enzyme
Novelty:  0.00435138
Score:  0.836
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 1 - inactivation of fast Na+ channels
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 1 - inactivation of fast Na+ channels
Potassium Channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
3
167
96.7
body mass index
4
3
4
84.6
P wave terminal force measurement
1
2
0
118
84.5
3
3
0
1.1
79.8
waist-hip ratio
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
167
96.7
body mass index
4
84.6
P wave terminal force measurement
0
118
84.5
0
1.1
79.8
waist-hip ratio
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily D member 3
VGNC:8056
744303
Mouse
MGI:1928743
56543
Rat
RGD:68394
65195
Dog
potassium voltage-gated channel subfamily D member 3
VGNC:42240
403758
Horse
potassium voltage-gated channel subfamily D member 3
VGNC:19270
100058973
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily D member 3
Mouse
Rat
Dog
potassium voltage-gated channel subfamily D member 3
Horse
potassium voltage-gated channel subfamily D member 3
Publication Statistics
PubMed Score 307.34
PubMed score by year
PubTator Score 225.48
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title