KCND3
Potassium voltage-gated channel subfamily D member 3
Protein Summary
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the ...more
- ENST00000302127
- ENSP00000306923
- ENSG00000171385
- ENST00000315987
- ENSP00000319591
- ENST00000369697
- ENSP00000358711
- KV4.3
- SCA19
- SCA22
- BRGDA9
- KCND3L
- KCND3S
- KSHIVB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.94 | ||
disease perturbation | 0.68 | ||
PubMedID | 0.64 | ||
transcription factor | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 307.34 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 307.34 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 8
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (8)
Active Ligands (6)
Protein-Protein Interactions (184)
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cardiac conduction | ||||
Reactome | Muscle contraction | ||||
Reactome | Neuronal System | ||||
Reactome | Phase 1 - inactivation of fast Na+ channels | ||||
Reactome | Potassium Channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cardiac conduction | ||||
Muscle contraction | ||||
Neuronal System | ||||
Phase 1 - inactivation of fast Na+ channels | ||||
Potassium Channels | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (4)
Components (8)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 3 | 167 | 96.7 | |||||
body mass index | 4 | 3 | 4 | 84.6 | |||||
P wave terminal force measurement | 1 | 2 | 0 | 118 | 84.5 | ||||
3 | 3 | 0 | 1.1 | 79.8 | |||||
waist-hip ratio | 2 | 2 | 2 | 70.4 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 167 | 96.7 | |||||
body mass index | 4 | 84.6 | |||||
P wave terminal force measurement | 0 | 118 | 84.5 | ||||
0 | 1.1 | 79.8 | |||||
waist-hip ratio | 2 | 70.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | potassium voltage-gated channel subfamily D member 3 | VGNC:8056 | 744303 | |||||
Mouse | MGI:1928743 | 56543 | ||||||
Rat | RGD:68394 | 65195 | ||||||
Dog | potassium voltage-gated channel subfamily D member 3 | VGNC:42240 | 403758 | |||||
Horse | potassium voltage-gated channel subfamily D member 3 | VGNC:19270 | 100058973 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | potassium voltage-gated channel subfamily D member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | potassium voltage-gated channel subfamily D member 3 | |||||
Horse | potassium voltage-gated channel subfamily D member 3 | |||||
Publication Statistics
PubMed Score 307.34
PubMed score by year
PubTator Score 225.48
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (59)
GeneRif Annotations (40)
Items per page:
0 of 0
PMID | Year | Title |
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