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Tdark
ZNF221
Zinc finger protein 221

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251269
  • ENSP00000251269
  • ENSG00000159905
  • ENST00000587682
  • ENSP00000467367
  • ENST00000592350
  • ENSP00000467446
  • ENST00000622072
  • ENSP00000477876
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.87
tissue sample
0.72
histone modification site profile
0.69
protein domain
0.58
cell line
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.06   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.06   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (4)
1 – 4 of 4
ZNF225
Tdark
Family:  TF
Novelty:  3.4791867
p_int:  0.986371465
p_ni:  4e-9
p_wrong:  0.013628531
Score:  0.68
Data Source:  BioPlex,STRINGDB
CDK11B
Tchem
Family:  Kinase
Novelty:  0.02711308
p_int:  0.960275944
p_ni:  0.039721573
p_wrong:  0.000002483
Score:  0.306
Data Source:  BioPlex,STRINGDB
ZNF284
Tdark
Family:  TF
Novelty:  3.72582741
p_int:  0.824136973
p_ni:  0.000002547
p_wrong:  0.17586048
Score:  0.485
Data Source:  BioPlex,STRINGDB
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.904
Data Source:  STRINGDB
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
81.5
low density lipoprotein cholesterol measurement
1
1
1
75.6
total cholesterol measurement
1
1
1
57.3
inflammatory biomarker measurement
1
1
0
32.2
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
81.5
low density lipoprotein cholesterol measurement
1
75.6
total cholesterol measurement
1
57.3
inflammatory biomarker measurement
0
32.2
17.8
Find similar targets by:
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 221
VGNC:2190
456104
Macaque
zinc finger protein 221
100423743
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 221
Macaque
zinc finger protein 221
Publication Statistics
PubMed Score 0.06
PubMed score by year