Tdark GNG8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Uniprot Accession IDs

• Q9UK08
• Q4VBM5

Gene Name

• GNG8

Ensembl ID

• ENST00000300873
• ENSP00000300873
• ENSG00000167414

Symbol

• GNG9
• GNGT9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.91
tissue	0.55
gene perturbation	0.53
cell line	0.48
kinase perturbation	0.48

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-8

DTO Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.92   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.92   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0