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Tdark
GNG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300873
  • ENSP00000300873
  • ENSG00000167414

Symbol
  • GNG9
  • GNGT9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.91
tissue
0.55
gene perturbation
0.53
cell line
0.48
kinase perturbation
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.16   (req: < 5)
View Publications
Gene RIFs: 2   (req: <= 3)
View Gene RIFs
Antibodies: 44   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.16   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (112)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
25 targets
R-HSA-418592
Reactome
ADP signalling through P2Y purinoceptor 12
22 targets
R-HSA-392170
Reactome
Activation of G protein gated Potassium channels
25 targets
R-HSA-1296041
Reactome
Activation of GABAB receptors
39 targets
R-HSA-991365
Reactome
Activation of kainate receptors upon glutamate binding
30 targets
R-HSA-451326
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
25 targets
R-HSA-418592
ADP signalling through P2Y purinoceptor 12
22 targets
R-HSA-392170
Activation of G protein gated Potassium channels
25 targets
R-HSA-1296041
Activation of GABAB receptors
39 targets
R-HSA-991365
Activation of kainate receptors upon glutamate binding
30 targets
R-HSA-451326
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
GTPase activity
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (557)
1 – 10 of 557
GNB1
Tbio
Novelty: 0.04716243
Score: 0.999
Data Source: STRINGDB
GNB4
Tbio
Novelty: 0.1530232
Score: 0.999
Data Source: STRINGDB
GNB2
Tbio
Novelty: 0.20536996
Score: 0.999
Data Source: STRINGDB
BRS3
Tchem
Family: GPCR
Novelty: 0.00563582
Score: 0.966
Data Source: STRINGDB
GNAZ
Tbio
Novelty: 0.02343957
Score: 0.957
Data Source: STRINGDB
GNAO1
Tbio
Novelty: 0.0056926
Score: 0.957
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.01077999
Score: 0.954
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.0018171
Score: 0.953
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.14784205
Score: 0.953
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.00176666
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  159.16

PubMed score by year
PubTator Score  12.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer