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Tbio
GDF2
Growth/differentiation factor 2

Protein Summary
Description
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000581492
  • ENSP00000463051
  • ENSG00000263761

Symbol
  • BMP9
  • BMP9
  • HHT5
  • BMP-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
protein domain
0.85
tissue
0.58
biological term
0.56
cell type or tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.88   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.88   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
ACVRL1
Tchem
Family:  Kinase
Novelty:  0.00310167
Score:  0.998
Data Source:  Reactome,STRINGDB
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.99
Data Source:  STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.99
Data Source:  STRINGDB
ENG
Tbio
Novelty:  0.00036729
Score:  0.989
Data Source:  STRINGDB
ACVR2A
Tchem
Family:  Kinase
Novelty:  0.0063932
Score:  0.981
Data Source:  STRINGDB
SMAD5
Tbio
Family:  TF
Novelty:  0.00405952
Score:  0.961
Data Source:  STRINGDB
SMAD9
Tbio
Family:  TF
Novelty:  0.00285887
Score:  0.959
Data Source:  STRINGDB
SMAD1
Tbio
Family:  TF
Novelty:  0.02348173
Score:  0.938
Data Source:  STRINGDB
FKBP1A
Tclin
Family:  Enzyme
Novelty:  0.00116174
Score:  0.913
Data Source:  STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
75.2
hemoglobin measurement
2
1
2
71.6
red blood cell density measurement
1
1
1
65.4
corneal topography
2
1
2
59
systolic blood pressure
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
75.2
hemoglobin measurement
2
71.6
red blood cell density measurement
1
65.4
corneal topography
2
59
systolic blood pressure
1
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
growth differentiation factor 2
711516
Mouse
MGI:1321394
12165
Rat
RGD:1586196
290921
Dog
growth differentiation factor 2
VGNC:41161
611149
Horse
growth differentiation factor 2
VGNC:18289
100051984
Species
Name
OMA
EggNOG
Inparanoid
Macaque
growth differentiation factor 2
Mouse
Rat
Dog
growth differentiation factor 2
Horse
growth differentiation factor 2
Publication Statistics
PubMed Score 322.88
PubMed score by year
PubTator Score 100.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title