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Tbio
ANAPC2
Anaphase-promoting complex subunit 2

Protein Summary
Description
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degrade ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323927
  • ENSP00000314004
  • ENSG00000176248

Symbol
  • APC2
  • KIAA1406
  • APC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
interacting protein
0.91
disease perturbation
0.79
histone modification site profile
0.79
transcription factor binding site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.25   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.25   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (405)
ANAPC5
Tbio
Family:  Enzyme
Novelty:  0.02102572
p_int:  0.999999992
p_ni:  8e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
C16orf87
Tdark
Novelty:  5.71664261
p_int:  0.999999972
p_ni:  2.8e-8
Score:  0.719
Data Source:  BioPlex,STRINGDB
CDC26
Tbio
Family:  Enzyme
Novelty:  0.07456358
p_int:  0.999999941
p_ni:  5.9e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC13
Tbio
Family:  Enzyme
Novelty:  0.06125489
p_int:  0.999999829
p_ni:  1.71e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.99999971
p_ni:  2.89e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC16
Tdark
Family:  Enzyme
Novelty:  0.06353035
p_int:  0.999999488
p_ni:  5.12e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MAGIX
Tdark
Novelty:  0.38577176
p_int:  0.999898193
p_ni:  0.000101783
p_wrong:  2.4e-8
Score:  0.536
Data Source:  BioPlex,STRINGDB
FZR1
Tbio
Novelty:  0.01599606
p_int:  0.99979932
p_ni:  0.000200679
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
TTLL1
Tdark
Family:  Enzyme
Novelty:  0.09244899
p_int:  0.99949914
p_ni:  0.000464575
p_wrong:  0.000036284
Score:  0.663
Data Source:  BioPlex,STRINGDB
GRAP2
Tbio
Novelty:  0.00503901
p_int:  0.997161073
p_ni:  0.002810164
p_wrong:  0.000028763
Score:  0.177
Data Source:  BioPlex,STRINGDB
Pathways (133)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
89.1
creatinine measurement
1
2
2
86.1
reticulocyte measurement
3
1
3
82.3
reticulocyte count
6
1
6
80.4
serum urea measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
89.1
creatinine measurement
2
86.1
reticulocyte measurement
3
82.3
reticulocyte count
6
80.4
serum urea measurement
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anaphase promoting complex subunit 2
VGNC:4610
465174
Macaque
anaphase promoting complex subunit 2
706384
Mouse
MGI:2139135
99152
Rat
RGD:1305546
296558
Dog
anaphase promoting complex subunit 2
VGNC:37849
491236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anaphase promoting complex subunit 2
Macaque
anaphase promoting complex subunit 2
Mouse
Rat
Dog
anaphase promoting complex subunit 2
Publication Statistics
PubMed Score 5.25
PubMed score by year
PubTator Score 2.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title