Tbio ANAPC2 Anaphase-promoting complex subunit 2

Protein Summary

Description

Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UJX6
• Q5VSG1
• Q96DG5
• Q96GG4
• Q9P2E1
• APC2

Gene Name

• ANAPC2

Ensembl ID

• ENST00000323927
• ENSP00000314004
• ENSG00000176248

Symbol

• APC2
• KIAA1406
• APC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
interacting protein	0.91
disease perturbation	0.79
histone modification site profile	0.79
transcription factor binding site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.25   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 250   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.25   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (405)

Explore Interacting Targets

1 – 10 of 405

• See Interactions on String-DB

ANAPC5

Tbio

Family:  Enzyme

Novelty:  0.02102572

p_int:  0.999999992

p_ni:  8e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

C16orf87

Tdark

Novelty:  5.71664261

p_int:  0.999999972

p_ni:  2.8e-8

Score:  0.719

Data Source:  BioPlex,STRINGDB

CDC26

Tbio

Family:  Enzyme

Novelty:  0.07456358

p_int:  0.999999941

p_ni:  5.9e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC13

Tbio

Family:  Enzyme

Novelty:  0.06125489

p_int:  0.999999829

p_ni:  1.71e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

CDC16

Tbio

Novelty:  0.00916715

p_int:  0.99999971

p_ni:  2.89e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC16

Tdark

Family:  Enzyme

Novelty:  0.06353035

p_int:  0.999999488

p_ni:  5.12e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

MAGIX

Tdark

Novelty:  0.38577176

p_int:  0.999898193

p_ni:  0.000101783

p_wrong:  2.4e-8

Score:  0.536

Data Source:  BioPlex,STRINGDB

FZR1

Tbio

Novelty:  0.01599606

p_int:  0.99979932

p_ni:  0.000200679

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

TTLL1

Tdark

Family:  Enzyme

Novelty:  0.09244899

p_int:  0.99949914

p_ni:  0.000464575

p_wrong:  0.000036284

Score:  0.663

Data Source:  BioPlex,STRINGDB

GRAP2

Tbio

Novelty:  0.00503901

p_int:  0.997161073

p_ni:  0.002810164

p_wrong:  0.000028763

Score:  0.177

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (3)

1 – 3 of 3

CALM2

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

CALM1

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

CALM3

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

Pathways (133)

Reactome (37)

KEGG (5)

PathwayCommons (1)

UniProt (1)

WikiPathways (89)

APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048
Reactome	APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
Reactome	APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Name	Explore in Pharos	Explore in Source
APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048
APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (1)

Components (3)

Processes (9)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
ubiquitin protein ligase binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (10)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	3	3	4		89.1
creatinine measurement	EFO_0004518	1	2	2		86.1
reticulocyte measurement	EFO_0010700	3	1	3		82.3
reticulocyte count	EFO_0007986	6	1	6		80.4
serum urea measurement	EFO_0009795	1	1	1		54.4

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5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	4		89.1
creatinine measurement	EFO_0004518	2		86.1
reticulocyte measurement	EFO_0010700	3		82.3
reticulocyte count	EFO_0007986	6		80.4
serum urea measurement	EFO_0009795	1		54.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Differentiation
Mitosis
Neurogenesis
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
creatinine measurement
eosinophil percentage of leukocytes
glomerular filtration rate
HbA1c measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
reticulocyte count
reticulocyte measurement
serum urea measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	anaphase promoting complex subunit 2	VGNC:4610	465174
Macaque	anaphase promoting complex subunit 2		706384
Mouse	anaphase promoting complex subunit 2	MGI:2139135	99152
Rat	anaphase promoting complex subunit 2	RGD:1305546	296558
Dog	anaphase promoting complex subunit 2	VGNC:37849	491236

Species	Name	OMA	EggNOG	Inparanoid
Chimp	anaphase promoting complex subunit 2
Macaque	anaphase promoting complex subunit 2
Mouse	anaphase promoting complex subunit 2
Rat	anaphase promoting complex subunit 2
Dog	anaphase promoting complex subunit 2

Publication Statistics

PubMed Score 5.25

PubMed score by year

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PubTator Score 2.79

PubTator score by year

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Related Publications

Text Mined References (33)

GeneRif Annotations (10)

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PMID	Year	Title