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Tbio
CDC23
Cell division cycle protein 23 homolog

Protein Summary
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394884
  • ENSP00000378348
  • ENSG00000094880
  • ENST00000394886
  • ENSP00000378350

Symbol
  • ANAPC8
  • APC8
  • CUT23
  • ANAPC8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
biological process
0.96
virus perturbation
0.96
histone modification site profile
0.88
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.67   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.67   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
5.5
Eczema
1
1
0
1
5.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
5.5
Eczema
0
1
5.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 23
VGNC:11875
462092
Macaque
cell division cycle 23
714000
Mouse
MGI:1098815
52563
Rat
RGD:1304819
291689
Dog
cell division cycle 23
VGNC:51703
481526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 23
Macaque
cell division cycle 23
Mouse
Rat
Dog
cell division cycle 23
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UJX2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (72)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (478)
1 – 10 of 478
ANAPC13
Tbio
Family: Enzyme
Novelty: 0.06125489
p_int: 0.999998592
p_ni: 0.000001407
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CDC26
Tbio
Family: Enzyme
Novelty: 0.07456358
p_int: 0.999997546
p_ni: 0.000002454
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC5
Tbio
Family: Enzyme
Novelty: 0.02102572
p_int: 0.99999748
p_ni: 0.000002516
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.999996688
p_ni: 0.000003312
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC16
Tdark
Family: Enzyme
Novelty: 0.06353035
p_int: 0.999991546
p_ni: 0.000008453
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
C16orf87
Tdark
Novelty: 5.71664261
p_int: 0.999981592
p_ni: 0.000018405
p_wrong: 3e-9
Score: 0.321
Data Source: BioPlex,STRINGDB
MAGIX
Tdark
Novelty: 0.38577176
p_int: 0.999922343
p_ni: 0.000077657
Score: 0.155
Data Source: BioPlex,STRINGDB
FZR1
Tbio
Novelty: 0.01599606
p_int: 0.998477496
p_ni: 0.001522504
Score: 0.999
Data Source: BioPlex,STRINGDB
PENK
Tbio
Novelty: 0.00074167
p_int: 0.998173061
p_ni: 0.001826937
p_wrong: 1e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
SCGN
Tbio
Novelty: 0.01434518
p_int: 0.997060247
p_ni: 0.002939752
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  56.67

PubMed score by year
PubTator Score  14.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer