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Tbio
OSGIN1
Oxidative stress-induced growth inhibitor 1

Protein Summary
Description
Regulates the differentiation and proliferation of normal cells through the regulation of cell death. This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343939
  • ENSP00000343376
  • ENSG00000140961
  • ENST00000361711
  • ENSP00000355374
  • ENST00000393306
  • ENSP00000376983

Symbol
  • OKL38
  • BDGI
  • OKL38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
virus perturbation
0.85
cell type or tissue
0.77
transcription factor binding site profile
0.72
transcription factor
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.93   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.93   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
99.1
low density lipoprotein cholesterol measurement
5
3
6
98.4
testosterone measurement
2
1
2
86.7
C-reactive protein measurement
1
1
1
82.2
apolipoprotein B measurement
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
99.1
low density lipoprotein cholesterol measurement
6
98.4
testosterone measurement
2
86.7
C-reactive protein measurement
1
82.2
apolipoprotein B measurement
1
52
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (27)
1 – 10 of 27
RPS6KA6
Tchem
Family: Kinase
Novelty: 0.03326451
p_int: 0.999998578
p_ni: 2.9e-8
p_wrong: 0.000001393
Score: 0.692
Data Source: BioPlex,STRINGDB
BTBD1
Tbio
Novelty: 0.19772296
p_int: 0.985370795
p_ni: 0.014620862
p_wrong: 0.000008343
Score: 0.234
Data Source: BioPlex,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.609
Data Source: STRINGDB
NDUFA1
Tclin
Family: Enzyme
Novelty: 0.00623739
Score: 0.58
Data Source: STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
Score: 0.576
Data Source: STRINGDB
COLEC10
Tbio
Novelty: 0.02593638
Score: 0.574
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00005849
Score: 0.564
Data Source: STRINGDB
PADI4
Tchem
Family: Enzyme
Novelty: 0.0024252
Score: 0.555
Data Source: STRINGDB
ATG101
Tbio
Novelty: 0.03407206
Score: 0.536
Data Source: STRINGDB
ENO1
Tchem
Family: Enzyme
Novelty: 0.00109178
Score: 0.526
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.93

PubMed score by year
PubTator Score  14.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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