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Tdark
ZNF180
Zinc finger protein 180

Protein Summary
Description
May be involved in transcriptional regulation. Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221327
  • ENSP00000221327
  • ENSG00000167384

Symbol
  • HHZ168
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor binding site profile
0.79
protein domain
0.58
cell line
0.54
kinase perturbation
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (9)
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.918
Data Source:  STRINGDB
TNFSF8
Tbio
Novelty:  0.01292216
Score:  0.514
Data Source:  STRINGDB
LGALS16
Tbio
Novelty:  0.41159587
Score:  0.505
Data Source:  STRINGDB
PPP2R3A
Tbio
Family:  Enzyme
Novelty:  0.0350873
Score:  0.502
Data Source:  STRINGDB
APOPT1
Tdark
Novelty:  0.05090202
Score:  0.493
Data Source:  STRINGDB
RNF7
Tbio
Novelty:  0.02532658
Score:  0.437
Data Source:  STRINGDB
ZFPM1
Tbio
Family:  TF
Novelty:  0.01061715
Score:  0.426
Data Source:  STRINGDB
ZNF474
Tdark
Novelty:  1.18085106
Score:  0.412
Data Source:  STRINGDB
CHST13
Tbio
Family:  Enzyme
Novelty:  0.15000853
Score:  0.4
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
10
10
99.7
low density lipoprotein cholesterol measurement
2
6
6
99.1
total cholesterol measurement
1
4
4
97.9
C-reactive protein measurement
2
2
2
78.7
1
3
0
7.1
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
10
99.7
low density lipoprotein cholesterol measurement
6
99.1
total cholesterol measurement
4
97.9
C-reactive protein measurement
2
78.7
0
7.1
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 180
VGNC:11470
456110
Macaque
zinc finger protein 180
712493
Mouse
MGI:1923701
210135
Rat
RGD:631380
246279
Dog
zinc finger protein 180
VGNC:48669
100685461
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 180
Macaque
zinc finger protein 180
Mouse
Rat
Dog
zinc finger protein 180
Publication Statistics
PubMed Score 3.76
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title