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Tbio
DNMT3L
DNA (cytosine-5)-methyltransferase 3-like

Protein Summary
Description
Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270172
  • ENSP00000270172
  • ENSG00000142182
  • ENST00000628202
  • ENSP00000486001
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
kinase perturbation
0.66
PubMedID
0.63
biological process
0.58
cell type or tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.66   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.66   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
DNA methylation (R-HSA-5334118)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA methylation
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
DNA methylation
Epigenetic regulation of gene expression
Gene expression (Transcription)
Protein-Protein Interactions (98)
1 – 10 of 98
DNMT3A
Tclin
Family: Epigenetic
Novelty: 0.00085974
Score: 0.99
Data Source: Reactome,STRINGDB
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.951
Data Source: STRINGDB
DNMT3B
Tchem
Family: Epigenetic
Novelty: 0.00118766
Score: 0.951
Data Source: Reactome,STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.951
Data Source: STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
Score: 0.932
Data Source: STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
Score: 0.927
Data Source: STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
Score: 0.91
Data Source: STRINGDB
HIST1H2AC
Tdark
Novelty: 0.4785744
Score: 0.904
Data Source: STRINGDB
H2AFB1
Tbio
Novelty: 0.08770329
Score: 0.901
Data Source: STRINGDB
H2AFV
Tbio
Novelty: 0.03561635
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.66

PubMed score by year
PubTator Score  63.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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