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Tbio
DNMT3L
DNA (cytosine-5)-methyltransferase 3-like

Protein Summary
Description
Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270172
  • ENSP00000270172
  • ENSG00000142182
  • ENST00000628202
  • ENSP00000486001
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
kinase perturbation
0.66
PubMedID
0.63
biological process
0.58
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.5   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.5   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
DNMT3A
Tclin
Family:  Epigenetic
Novelty:  0.00085974
Score:  0.99
Data Source:  Reactome,STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.951
Data Source:  STRINGDB
DNMT3B
Tchem
Family:  Epigenetic
Novelty:  0.00118766
Score:  0.951
Data Source:  Reactome,STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.951
Data Source:  STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
Score:  0.932
Data Source:  STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
Score:  0.927
Data Source:  STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.91
Data Source:  STRINGDB
HIST1H2AC
Tdark
Novelty:  0.4785744
Score:  0.904
Data Source:  STRINGDB
H2AFB1
Tbio
Novelty:  0.08770329
Score:  0.901
Data Source:  STRINGDB
H2AFV
Tbio
Novelty:  0.03561635
Score:  0.901
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
DNA methylation (R-HSA-5334118)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA methylation
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
DNA methylation
Epigenetic regulation of gene expression
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
90.1
Addison disease
1
2
0
2.8
88.2
eosinophil count
3
2
3
85.1
eosinophil percentage of leukocytes
2
2
2
82.2
1
1
0
1.1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.1
Addison disease
0
2.8
88.2
eosinophil count
3
85.1
eosinophil percentage of leukocytes
2
82.2
0
1.1
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA methyltransferase 3 like
VGNC:14661
470099
Macaque
DNA methyltransferase 3 like
722184
Mouse
MGI:1859287
54427
Rat
RGD:1303239
309680
Dog
DNA methyltransferase 3 like
608536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA methyltransferase 3 like
Macaque
DNA methyltransferase 3 like
Mouse
Rat
Dog
DNA methyltransferase 3 like
Publication Statistics
PubMed Score 124.50
PubMed score by year
PubTator Score 63.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title