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Tbio
DCTN4
Dynactin subunit 4

Protein Summary
Description
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000424236
  • ENSP00000411251
  • ENSG00000132912
  • ENST00000446090
  • ENSP00000414906
  • ENST00000447998
  • ENSP00000416968

Symbol
  • P62
  • DYN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
histone modification site profile
0.8
kinase perturbation
0.76
transcription factor perturbation
0.74
cellular component
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (19)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cellular responses to external stimuli
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (222)
1 – 10 of 222
DCTN5
Tdark
Novelty: 0.30523995
p_int: 0.999993891
p_ni: 0.000006109
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty: 0.93301435
p_int: 0.999969722
p_ni: 0.000030278
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty: 0.15424927
p_int: 0.999950055
p_ni: 0.000049945
Score: 0.996
Data Source: BioPlex,STRINGDB
DCTN2
Tbio
Novelty: 0.01298814
p_int: 0.999948238
p_ni: 0.000051762
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
DCTN1
Tbio
Novelty: 0.00789738
p_int: 0.999889872
p_ni: 0.000110128
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Tdark
Novelty: 0.27435063
p_int: 0.999713444
p_ni: 0.000286556
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
KLHL2
Tbio
Novelty: 0.00508721
p_int: 0.999241327
p_ni: 0.000758673
Score: 0.405
Data Source: BioPlex,STRINGDB
RIC8A
Tbio
Novelty: 0.01968858
p_int: 0.998277052
p_ni: 0.001722948
Score: 0.696
Data Source: BioPlex,STRINGDB
ACTR1A
Tbio
Novelty: 0.1045483
p_int: 0.996611013
p_ni: 0.003388987
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
DEFB127
Tbio
Novelty: 0.21093001
p_int: 0.991836052
p_ni: 0.008163948
Score: 0.69
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.51

PubMed score by year
PubTator Score  14.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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