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Tbio
DDX41
Probable ATP-dependent RNA helicase DDX41

Protein Summary
Description
Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000507955
  • ENSP00000422753
  • ENSG00000183258

Symbol
  • ABS
  • ABS
  • MPLPF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
molecular function
0.98
kinase perturbation
0.96
protein domain
0.85
ligand (protein) perturbation
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.39   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.39   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 41
VGNC:11915
462310
Macaque
DEAD-box helicase 41
700742
Mouse
MGI:1920185
72935
Rat
RGD:1311758
314336
Dog
DEAD-box helicase 41
VGNC:39857
479274
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 41
Macaque
DEAD-box helicase 41
Mouse
Rat
Dog
DEAD-box helicase 41
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
IRF3-mediated induction of type I IFN
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of innate immune responses to cytosolic DNA
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Immune System
Innate Immune System
Regulation of innate immune responses to cytosolic DNA
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (300)
1 – 10 of 300
NKAP
Tbio
Novelty: 0.04982584
p_int: 0.99998384
p_ni: 0.00001616
Score: 0.726
Data Source: BioPlex,STRINGDB
ANKRD50
Tdark
Novelty: 0.7929169
p_int: 0.999866694
p_ni: 3.07e-7
p_wrong: 0.000132999
Score: 0.246
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.99288022
p_ni: 0.00711978
Score: 0.367
Data Source: BioPlex,STRINGDB
NOS1AP
Tbio
Family: Enzyme
Novelty: 0.0076555
p_int: 0.98853287
p_ni: 0.01146713
Score: 0.773
Data Source: BioPlex,STRINGDB
PNN
Tbio
Novelty: 0.01395394
p_int: 0.976765769
p_ni: 0.023234231
Score: 0.568
Data Source: BioPlex,STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.966464656
p_ni: 0.033535344
Score: 0.255
Data Source: BioPlex,STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
p_int: 0.898679117
p_ni: 0.101320883
Score: 0.248
Data Source: BioPlex,STRINGDB
SRRM2
Tbio
Novelty: 0.03914644
p_int: 0.8178452
p_ni: 0.1821548
Score: 0.668
Data Source: BioPlex,STRINGDB
RNPS1
Tbio
Novelty: 0.03203224
p_int: 0.807966688
p_ni: 0.192033312
Score: 0.687
Data Source: BioPlex,STRINGDB
BRMS1L
Tbio
Novelty: 0.01578276
p_int: 0.781050496
p_ni: 0.218941018
p_wrong: 0.000008486
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  61.39

PubMed score by year
PubTator Score  35.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer