Tbio MID2 Probable E3 ubiquitin-protein ligase MID2

Protein Summary

Description

May play a role in microtubule stabilization. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9UJV3
• A6NEL8
• A6PVI5
• Q5JYF5
• Q8WWK1
• Q9UJR9

Gene Name

• MID2

Ensembl ID

• ENST00000262843
• ENSP00000262843
• ENSG00000080561
• ENST00000443968
• ENSP00000413976

Symbol

• FXY2
• RNF60
• TRIM1
• FXY2
• RNF60
• TRIM1
• MRX101

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.96
kinase perturbation	0.71
molecular function	0.7
biological process	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 701.23   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 701.23   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0