LEF1
Lymphoid enhancer-binding factor 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
PubMedID | 0.98 | ||
hub protein | 0.85 | ||
transcription factor | 0.83 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Binding of TCF/LEF:CTNNB1 to target gene promoters | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Deactivation of the beta-catenin transactivating complex | ||||
Reactome | Degradation of beta-catenin by the destruction complex | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Binding of TCF/LEF:CTNNB1 to target gene promoters | ||||
Ca2+ pathway | ||||
Deactivation of the beta-catenin transactivating complex | ||||
Degradation of beta-catenin by the destruction complex | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hair color | 1 | 2 | 0 | 1.2 | 75.7 | ||||
testosterone measurement | 2 | 1 | 2 | 71.9 | |||||
2 | 2 | 0 | 1.2 | 53.1 | |||||
1 | 1 | 0 | 1.1 | 49.5 | |||||
heel bone mineral density | 1 | 1 | 1 | 31.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hair color | 0 | 1.2 | 75.7 | ||||
testosterone measurement | 2 | 71.9 | |||||
0 | 1.2 | 53.1 | |||||
0 | 1.1 | 49.5 | |||||
heel bone mineral density | 1 | 31.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | lymphoid enhancer binding factor 1 | VGNC:6477 | 461425 | |||||
Macaque | lymphoid enhancer binding factor 1 | 695776 | ||||||
Mouse | MGI:96770 | 16842 | ||||||
Rat | RGD:620241 | 161452 | ||||||
Dog | lymphoid enhancer binding factor 1 | VGNC:42630 | 478507 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | lymphoid enhancer binding factor 1 | |||||
Macaque | lymphoid enhancer binding factor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | lymphoid enhancer binding factor 1 | |||||
PMID | Year | Title |
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