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Tchem
LEF1
Lymphoid enhancer-binding factor 1

Protein Summary
Description
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. This gene encodes a transcription factor belonging to a family of pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265165
  • ENSP00000265165
  • ENSG00000138795
  • ENST00000379951
  • ENSP00000369284
  • ENST00000438313
  • ENSP00000406176
  • ENST00000506680
  • ENSP00000422334
  • ENST00000510624
  • ENSP00000422840

Symbol
  • LEF-1
  • TCF10
  • TCF7L3
  • TCF1ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
PubMedID
0.98
hub protein
0.85
transcription factor
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 527.67   (req: < 5)
Gene RIFs: 126   (req: <= 3)
Antibodies: 722   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 527.67   (req: >= 5)
Gene RIFs: 126   (req: > 3)
Antibodies: 722   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 89
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3222139
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
89.6
2
2
0
1.2
63
hair color
1
2
0
1.2
57.2
1
1
0
1.1
42.8
Calcium channel blocker use measurement
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
89.6
0
1.2
63
hair color
0
1.2
57.2
0
1.1
42.8
Calcium channel blocker use measurement
1
6
Pathways (83)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Ca2+ pathway
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Binding of TCF/LEF:CTNNB1 to target gene promoters
Ca2+ pathway
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Gene Ontology Terms (95)
Items per page:
10
1 – 10 of 22
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (312)
1 – 10 of 312
PRMT6
Tchem
Family: Epigenetic
Novelty: 0.01734208
p_int: 0.901663692
p_ni: 0.0983363
p_wrong: 7e-9
Score: 0.288
Data Source: BioPlex,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.999
Data Source: Reactome,STRINGDB
AXIN2
Tchem
Novelty: 0.00273189
Score: 0.988
Data Source: STRINGDB
NLK
Tchem
Family: Kinase
Novelty: 0.01512201
Score: 0.986
Data Source: Reactome,STRINGDB
PITX2
Tbio
Family: TF
Novelty: 0.00216568
Score: 0.982
Data Source: STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.981
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.978
Data Source: Reactome,STRINGDB
TLE1
Tbio
Novelty: 0.00594261
Score: 0.975
Data Source: Reactome,STRINGDB
CCND1
Tchem
Novelty: 0.0001186
Score: 0.969
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.968
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  527.67

PubMed score by year
PubTator Score  365.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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