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Tbio
FBXL7
F-box/LRR-repeat protein 7

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest. This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000504595
  • ENSP00000423630
  • ENSG00000183580
  • ENST00000510662
  • ENSP00000425184

Symbol
  • FBL6
  • FBL7
  • KIAA0840
  • FBL6
  • FBL7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
cell type or tissue
0.85
PubMedID
0.72
disease perturbation
0.68
microRNA
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.67   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.67   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (411)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.979
Data Source:  Reactome,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
Score:  0.969
Data Source:  Reactome,STRINGDB
FBXL18
Tdark
Novelty:  0.33137957
Score:  0.969
Data Source:  STRINGDB
CCNF
Tbio
Novelty:  0.01288697
Score:  0.967
Data Source:  STRINGDB
FBXO41
Tbio
Novelty:  0.19719067
Score:  0.965
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.965
Data Source:  Reactome,STRINGDB
FBXW7
Tbio
Novelty:  0.00180856
Score:  0.958
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.949
Data Source:  STRINGDB
BTRC
Tbio
Novelty:  0.00293475
Score:  0.946
Data Source:  STRINGDB
FBXO9
Tbio
Novelty:  0.2145394
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Cell Cycle
Cell Cycle, Mitotic
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
1
1
0
10.7
68.3
white matter integrity
1
1
1
49.1
Alzheimer disease
1
1
0
1.6
42.5
cortical surface area measurement
1
1
0
6.5
35.2
cortical thickness
1
1
0
6.5
33.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
0
10.7
68.3
white matter integrity
1
49.1
Alzheimer disease
0
1.6
42.5
cortical surface area measurement
0
6.5
35.2
cortical thickness
0
6.5
33.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 7
VGNC:54160
471460
Macaque
F-box and leucine rich repeat protein 7
699367
Mouse
MGI:3052506
448987
Rat
RGD:1305813
361907
Dog
F-box and leucine rich repeat protein 7
VGNC:50891
489262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 7
Macaque
F-box and leucine rich repeat protein 7
Mouse
Rat
Dog
F-box and leucine rich repeat protein 7
Publication Statistics
PubMed Score 17.67
PubMed score by year
PubTator Score 5.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title