Protein Summary
Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
- ENST00000378789
- ENSP00000368066
- ENSG00000101323
- GOX1
- HAOX1
- GOX
- GOX1
- HAOX1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.9 | ||
cellular component | 0.69 | ||
cell type or tissue | 0.61 | ||
gene perturbation | 0.6 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2025.62 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 350 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2025.62 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 350 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (10)
Protein-Protein Interactions (127)
CCAR2
Novelty: 0.07397743
p_int: 0.999998552
p_ni: 0.000001448
Score: 0.842
Data Source: BioPlex,STRINGDB
KCNAB2
Family: IC
Novelty: 0.01752175
p_int: 0.937255024
p_ni: 0.062744847
p_wrong: 1.28e-7
Score: 0.878
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (5)
KEGG (4)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glyoxylate metabolism and glycine degradation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Peroxisomal protein import | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glyoxylate metabolism and glycine degradation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Peroxisomal protein import | ||||
Protein localization | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (8)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sleep duration | 1 | 1 | 1 | 26.6 | |||||
triglyceride measurement | 1 | 1 | 1 | 26.6 | |||||
1 | 1 | 0 | 1.4 | 11.9 | |||||
4 | 1 | 0 | 1.1 | 10.1 | |||||
1 | 1 | 0 | 1.2 | 3.9 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sleep duration | 1 | 26.6 | |||||
triglyceride measurement | 1 | 26.6 | |||||
0 | 1.4 | 11.9 | |||||
0 | 1.1 | 10.1 | |||||
0 | 1.2 | 3.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hydroxyacid oxidase 1 | VGNC:9867 | 747888 | |||||
Macaque | hydroxyacid oxidase 1 | 718360 | ||||||
Mouse | MGI:96011 | 15112 | ||||||
Rat | RGD:1589750 | 311446 | ||||||
Dog | hydroxyacid oxidase 1 | VGNC:41590 | 485774 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hydroxyacid oxidase 1 | |||||
Macaque | hydroxyacid oxidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hydroxyacid oxidase 1 | |||||
Publication Statistics
PubMed Score 2025.62
PubMed score by year
PubTator Score 900.08
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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