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Tchem
HAO1
Hydroxyacid oxidase 1

Protein Summary
Description
Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378789
  • ENSP00000368066
  • ENSG00000101323

Symbol
  • GOX1
  • HAOX1
  • GOX
  • GOX1
  • HAOX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cellular component
0.69
cell type or tissue
0.61
gene perturbation
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1164.84   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1164.84   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Peroxisomal protein import
Protein localization
Gene Ontology Terms (16)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (127)
1 – 10 of 127
CCAR2
Tbio
Novelty: 0.02010626
p_int: 0.999998552
p_ni: 0.000001448
Score: 0.842
Data Source: BioPlex,STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.02072106
p_int: 0.937255024
p_ni: 0.062744847
p_wrong: 1.28e-7
Score: 0.878
Data Source: BioPlex,STRINGDB
AGXT
Tbio
Family: Enzyme
Novelty: 0.00130886
Score: 0.99
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00022628
Score: 0.972
Data Source: STRINGDB
PIPOX
Tbio
Family: Enzyme
Novelty: 0.00144303
Score: 0.972
Data Source: STRINGDB
GNPAT
Tchem
Family: Enzyme
Novelty: 0.0152005
Score: 0.968
Data Source: STRINGDB
BAAT
Tbio
Family: Enzyme
Novelty: 0.0194259
Score: 0.965
Data Source: STRINGDB
GRHPR
Tbio
Family: Enzyme
Novelty: 0.01167728
Score: 0.965
Data Source: STRINGDB
LONP2
Tbio
Family: Enzyme
Novelty: 0.06368768
Score: 0.963
Data Source: STRINGDB
ECH1
Tbio
Family: Enzyme
Novelty: 0.04455822
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  1164.84

PubMed score by year
PubTator Score  900.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer