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Tbio
ERRFI1
ERBB receptor feedback inhibitor 1

Protein Summary
Description
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinj ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377482
  • ENSP00000366702
  • ENSG00000116285

Symbol
  • MIG6
  • MIG6
  • RALT
  • MIG-6
  • GENE-33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.94
transcription factor binding site profile
0.89
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.08   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.08   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
85.1
2
2
0
1.1
71.8
1
1
0
1.1
64.9
BMI-adjusted waist circumference
1
1
1
33.1
hair color
1
1
0
1.2
32.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
85.1
0
1.1
71.8
0
1.1
64.9
BMI-adjusted waist circumference
1
33.1
hair color
0
1.2
32.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ERBB receptor feedback inhibitor 1
VGNC:534
469787
Mouse
MGI:1921405
74155
Rat
RGD:1307599
313729
Dog
ERBB receptor feedback inhibitor 1
VGNC:40469
489636
Horse
ERBB receptor feedback inhibitor 1
VGNC:17677
100052062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ERBB receptor feedback inhibitor 1
Mouse
Rat
Dog
ERBB receptor feedback inhibitor 1
Horse
ERBB receptor feedback inhibitor 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UJM3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (27)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (31)
1 – 10 of 31
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.99995622
p_wrong:  0.00004378
Score:  0.463
Data Source:  BioPlex,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.992
Data Source:  STRINGDB
ERBB2
Tclin
Family:  Kinase
Novelty:  0.00003761
Score:  0.98
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.899
Data Source:  STRINGDB
ERBB3
Tclin
Family:  Kinase
Novelty:  0.000868
Score:  0.813
Data Source:  STRINGDB
ERBB4
Tclin
Family:  Kinase
Novelty:  0.00112919
Score:  0.778
Data Source:  STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.641
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.585
Data Source:  STRINGDB
SPAG4
Tbio
Novelty:  0.03721621
Score:  0.582
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.551
Data Source:  STRINGDB
Publication Statistics
PubMed Score  100.08

PubMed score by year
PubTator Score  64.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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