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Tbio
ERRFI1
ERBB receptor feedback inhibitor 1

Protein Summary
Description
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinj ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377482
  • ENSP00000366702
  • ENSG00000116285

Symbol
  • MIG6
  • MIG6
  • RALT
  • MIG-6
  • GENE-33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.94
transcription factor binding site profile
0.89
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.4   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.4   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (27)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (31)
1 – 10 of 31
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.99995622
p_wrong: 0.00004378
Score: 0.463
Data Source: BioPlex,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.992
Data Source: STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.98
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.899
Data Source: STRINGDB
ERBB3
Tclin
Family: Kinase
Novelty: 0.000868
Score: 0.813
Data Source: STRINGDB
ERBB4
Tclin
Family: Kinase
Novelty: 0.00112919
Score: 0.778
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.641
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.585
Data Source: STRINGDB
SPAG4
Tbio
Novelty: 0.03721621
Score: 0.582
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.551
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.40

PubMed score by year
PubTator Score  64.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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