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Tdark
TSR3
Ribosome biogenesis protein TSR3 homolog

Protein Summary
Description
Probable pre-rRNA processing protein involved in ribosome biogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000007390
  • ENSP00000007390
  • ENSG00000007520

Symbol
  • C16orf42
  • UND313L
  • C16orf42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.87
kinase perturbation
0.71
tissue sample
0.67
transcription factor binding site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
71.5
myeloid white cell count
1
1
1
70
leukocyte count
1
1
1
62.1
inflammatory biomarker measurement
1
1
0
50.6
56.4
reticulocyte measurement
2
1
2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
71.5
myeloid white cell count
1
70
leukocyte count
1
62.1
inflammatory biomarker measurement
0
50.6
56.4
reticulocyte measurement
2
48.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TSR3, acp transferase ribosome maturation factor
VGNC:10143
100608677
Macaque
TSR3, acp transferase ribosome maturation factor
677691
Mouse
MGI:1915577
68327
Rat
RGD:1565744
360494
Dog
TSR3, acp transferase ribosome maturation factor
VGNC:47931
479890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TSR3, acp transferase ribosome maturation factor
Macaque
TSR3, acp transferase ribosome maturation factor
Mouse
Rat
Dog
TSR3, acp transferase ribosome maturation factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UJK0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (73)
1 – 10 of 73
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999110199
p_ni:  0.000889801
Data Source:  BioPlex
MAF1
Tbio
Family:  Enzyme
Novelty:  0.01060279
p_int:  0.995245643
p_ni:  0.004754356
p_wrong:  1e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
MEF2A
Tbio
Family:  TF
Novelty:  0.00439393
p_int:  0.994249057
p_ni:  0.005750942
p_wrong:  1e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.99322143
p_ni:  0.00677857
Data Source:  BioPlex
REL
Tbio
Family:  TF
Novelty:  0.00038265
p_int:  0.993085788
p_ni:  0.006914212
Score:  0.193
Data Source:  BioPlex,STRINGDB
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.988870532
p_ni:  0.011129464
p_wrong:  4e-9
Data Source:  BioPlex
MTMR7
Tbio
Family:  Enzyme
Novelty:  0.1707096
p_int:  0.987532532
p_ni:  0.012467468
Score:  0.191
Data Source:  BioPlex,STRINGDB
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
p_int:  0.986310364
p_ni:  0.013689636
Score:  0.392
Data Source:  BioPlex,STRINGDB
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.986030451
p_ni:  0.013969549
Data Source:  BioPlex
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.9728286
p_ni:  0.02717135
p_wrong:  5.1e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  10.34

PubMed score by year
PubTator Score  2.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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