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Tbio
GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

Protein Summary
Description
Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors. This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204679
  • ENSP00000204679
  • ENSG00000090581

Symbol
  • C16orf27
  • GNPTAG
  • RJD9
  • GNPTAG
  • LP2537
  • C16orf27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
kinase perturbation
0.71
tissue
0.63
cellular component
0.58
cell type or tissue
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.17   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.17   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SPSB3
Tdark
Novelty:  0.07215887
p_int:  0.995259938
p_ni:  0.004619125
p_wrong:  0.000120937
Score:  0.255
Data Source:  BioPlex,STRINGDB
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.966990975
p_ni:  0.033008994
p_wrong:  3.1e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
GNPTAB
Tbio
Family:  Enzyme
Novelty:  0.00336101
p_int:  0.818540755
p_ni:  0.18145904
p_wrong:  2.05e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
ZPLD1
Tbio
Novelty:  0.19418088
p_int:  0.783861446
p_ni:  0.216138541
p_wrong:  1.3e-8
Score:  0.806
Data Source:  BioPlex,STRINGDB
NAGPA
Tbio
Family:  Enzyme
Novelty:  0.03136768
Score:  0.91
Data Source:  STRINGDB
GANAB
Tchem
Family:  Enzyme
Novelty:  0.01211958
Score:  0.821
Data Source:  STRINGDB
GANC
Tchem
Family:  Enzyme
Novelty:  0.02123234
Score:  0.821
Data Source:  STRINGDB
BSG
Tbio
Novelty:  0.0010285
Score:  0.719
Data Source:  STRINGDB
IGF2R
Tchem
Novelty:  0.00138374
Score:  0.713
Data Source:  STRINGDB
SBK1
Tchem
Family:  Kinase
Novelty:  0.05227715
Score:  0.615
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
71.5
myeloid white cell count
1
1
1
70
leukocyte count
1
1
1
62.1
inflammatory biomarker measurement
1
1
0
50.6
56.4
reticulocyte measurement
2
1
2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
71.5
myeloid white cell count
1
70
leukocyte count
1
62.1
inflammatory biomarker measurement
0
50.6
56.4
reticulocyte measurement
2
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetylglucosamine-1-phosphate transferase subunit gamma
VGNC:9005
746034
Mouse
MGI:2147006
214505
Rat
RGD:1311614
287134
Dog
N-acetylglucosamine-1-phosphate transferase subunit gamma
VGNC:41335
100856506
Horse
N-acetylglucosamine-1-phosphate transferase subunit gamma
VGNC:18448
100067580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetylglucosamine-1-phosphate transferase subunit gamma
Mouse
Rat
Dog
N-acetylglucosamine-1-phosphate transferase subunit gamma
Horse
N-acetylglucosamine-1-phosphate transferase subunit gamma
Publication Statistics
PubMed Score 32.17
PubMed score by year
PubTator Score 25.30
PubTator score by year
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Related Publications
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PMID
Year
Title