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Tbio
METRN
Meteorin

Protein Summary
Description
Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity). Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000568223
  • ENSP00000455068
  • ENSG00000103260

Symbol
  • C16orf23
  • C16orf23
  • c380A1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
PubMedID
0.66
small molecule perturbation
0.65
tissue sample
0.65
cell type or tissue
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
9
10
91.7
BMI-adjusted waist circumference
1
7
7
82.8
cancer antigen 125 measurement
1
3
3
77.9
mean corpuscular volume
1
1
1
74.6
mean reticulocyte volume
1
1
1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
91.7
BMI-adjusted waist circumference
7
82.8
cancer antigen 125 measurement
3
77.9
mean corpuscular volume
1
74.6
mean reticulocyte volume
1
72.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1917333
70083
Rat
RGD:1306222
287151
Horse
meteorin, glial cell differentiation regulator
VGNC:20114
100147618
Cow
meteorin, glial cell differentiation regulator
VGNC:31398
515528
Pig
meteorin, glial cell differentiation regulator
100519829
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
meteorin, glial cell differentiation regulator
Cow
meteorin, glial cell differentiation regulator
Pig
meteorin, glial cell differentiation regulator
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UJH8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (61)
1 – 10 of 61
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.999943598
p_ni:  0.000049896
p_wrong:  0.000006506
Data Source:  BioPlex
A2M
Tbio
Novelty:  0.00070446
p_int:  0.999916634
p_ni:  0.000002244
p_wrong:  0.000081122
Score:  0.221
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.989725607
p_ni:  0.000065953
p_wrong:  0.01020844
Score:  0.183
Data Source:  BioPlex,STRINGDB
VWC2
Tdark
Novelty:  0.30211591
Score:  0.676
Data Source:  STRINGDB
FNDC5
Tbio
Novelty:  0.0015827
Score:  0.64
Data Source:  STRINGDB
EGLN3
Tclin
Novelty:  0.00643992
Score:  0.64
Data Source:  STRINGDB
KLHDC8B
Tbio
Novelty:  0.15409379
Score:  0.631
Data Source:  STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.626
Data Source:  STRINGDB
KBTBD12
Tdark
Novelty:  3.42794501
Score:  0.625
Data Source:  STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
Score:  0.609
Data Source:  STRINGDB
Publication Statistics
PubMed Score  29.02

PubMed score by year
PubTator Score  7.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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