Tbio TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Protein Summary

Description

Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q9UJA5
• B4DUV6
• Q76P92
• Q9BQV5
• Q9ULR7
• Q9Y2Z8

Gene Name

• TRMT6

Ensembl ID

• ENST00000203001
• ENSP00000203001
• ENSG00000089195
• ENST00000453074
• ENSP00000392070

Symbol

• KIAA1153
• TRM6
• GCD10
• CGI-09
• Gcd10p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
histone modification site profile	0.9
interacting protein	0.9
virus perturbation	0.83
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Trna (Adenine(58)-n(1))-methyltransferase Non-catalytic Subunit Trm6

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Trna (Adenine(58)-n(1))-methyltransferase Non-catalytic Subunit Trm6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (254)

Explore Interacting Targets

1 – 10 of 254

• See Interactions on String-DB

TRMT61A

Tbio

Family:  Enzyme

Novelty:  0.04443394

p_int:  0.999999992

p_ni:  4e-9

p_wrong:  5e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

PSME3

Tbio

Novelty:  0.01051254

p_int:  0.999417576

p_ni:  0.000582424

Score:  0.234

Data Source:  BioPlex,STRINGDB

PPARD

Tchem

Family:  NR

Novelty:  0.00271873

p_int:  0.994272102

p_ni:  0.005727898

Score:  0.228

Data Source:  BioPlex,STRINGDB

LAMTOR5

Tbio

Novelty:  0.003692

p_int:  0.993973279

p_ni:  0.00602672

p_wrong:  1e-9

Data Source:  BioPlex

KLHL22

Tbio

Novelty:  0.24456252

p_int:  0.992128321

p_ni:  0.00787167

p_wrong:  8e-9

Data Source:  BioPlex

LRRC8E

Tbio

Novelty:  0.15689344

p_int:  0.986323895

p_ni:  0.013676103

p_wrong:  2e-9

Score:  0.205

Data Source:  BioPlex,STRINGDB

SRP9

Tbio

Novelty:  0.02243103

p_int:  0.982502155

p_ni:  0.017497843

p_wrong:  2e-9

Score:  0.775

Data Source:  BioPlex,STRINGDB

FKBP5

Tchem

Family:  Enzyme

Novelty:  0.00214511

p_int:  0.970554914

p_ni:  0.029445086

Score:  0.166

Data Source:  BioPlex,STRINGDB

ACAA1

Tbio

Family:  Enzyme

Novelty:  0.00710465

p_int:  0.968875283

p_ni:  0.031123949

p_wrong:  7.68e-7

Data Source:  BioPlex

CBWD1

Tbio

Novelty:  0.04321511

p_int:  0.916768802

p_ni:  0.083231028

p_wrong:  1.7e-7

Score:  0.178

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	tRNA modification in the nucleus and cytosol	43 targets	R-HSA-6782315
Reactome	tRNA processing	123 targets	R-HSA-72306

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
tRNA modification in the nucleus and cytosol	43 targets	R-HSA-6782315
tRNA processing	123 targets	R-HSA-72306

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (2)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menopause	EFO_0004704	4	3	5		97.2
uterine fibroid	EFO_0000731	1	1	0	1.2	42.3
anti-Mullerian hormone measurement	EFO_0004769	1	1	1		39.6
Menorrhagia	HP_0000132	1	1	0	1.2	17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menopause	EFO_0004704	5		97.2
uterine fibroid	EFO_0000731	0	1.2	42.3
anti-Mullerian hormone measurement	EFO_0004769	1		39.6
Menorrhagia	HP_0000132	0	1.2	17.8

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
tRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
age at menopause
anti-Mullerian hormone measurement
Menorrhagia
uterine fibroid

IDG Resources

No IDG generated resources found

Orthologs (17)

1 – 5 of 17

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tRNA methyltransferase 6	VGNC:6289	747713
Macaque	tRNA methyltransferase 6		718229
Mouse	tRNA methyltransferase 6	MGI:1914176	66926
Rat	tRNA methyltransferase 6	RGD:1308877	311441
Dog	tRNA methyltransferase 6	VGNC:54738	485777

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tRNA methyltransferase 6
Macaque	tRNA methyltransferase 6
Mouse	tRNA methyltransferase 6
Rat	tRNA methyltransferase 6
Dog	tRNA methyltransferase 6

Publication Statistics

PubMed Score 16.23

PubMed score by year

Reset Zoom

PubTator Score 3.52

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (12)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title