Tbio MCM8 DNA helicase MCM8

Protein Summary

Description

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093). The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q9UJA3
• B2RBG7
• D3DW08
• E7EQU7
• Q495R4
• Q495R6
• Q495R7
• Q86US4
• Q969I5

Gene Name

• MCM8

Ensembl ID

• ENST00000265187
• ENSP00000265187
• ENSG00000125885
• ENST00000378883
• ENSP00000368161
• ENST00000378886
• ENSP00000368164
• ENST00000378896
• ENSP00000368174
• ENST00000610722
• ENSP00000478141

Symbol

• C20orf154
• POF10
• C20orf154
• dJ967N21.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
histone modification site profile	0.9
virus perturbation	0.79
protein domain	0.73
phenotype	0.72

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Dna Helicase Mcm8

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Dna Helicase Mcm8

Protein / Hydrolase / Dna Helicase Mcm8

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Dna Helicase Mcm8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.85   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 249   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.85   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0