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Tbio
STAG3
Cohesin subunit SA-3

Protein Summary
Description
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317296
  • ENSP00000319318
  • ENSG00000066923
  • ENST00000394018
  • ENSP00000377586
  • ENST00000426455
  • ENSP00000400359
  • ENST00000620100
  • ENSP00000484098
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.78
gene perturbation
0.76
virus perturbation
0.72
PubMedID
0.67
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.26   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.26   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
SMC3
Tbio
Novelty:  0.00474377
Score:  0.997
Data Source:  STRINGDB
SMC1B
Tbio
Novelty:  0.0369537
Score:  0.993
Data Source:  STRINGDB
SMC1A
Tchem
Novelty:  0.00898427
Score:  0.993
Data Source:  STRINGDB
REC8
Tbio
Novelty:  0.00732742
Score:  0.992
Data Source:  STRINGDB
RAD21
Tbio
Novelty:  0.00270936
Score:  0.991
Data Source:  STRINGDB
RAD21L1
Tdark
Novelty:  0.11750397
Score:  0.99
Data Source:  STRINGDB
SYCP1
Tbio
Novelty:  0.01493554
Score:  0.975
Data Source:  STRINGDB
SYCP3
Tbio
Novelty:  0.00443901
Score:  0.973
Data Source:  STRINGDB
SYCP2
Tbio
Novelty:  0.05040533
Score:  0.973
Data Source:  STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
78.3
reticulocyte measurement
2
2
2
63.1
FEV/FEC ratio
1
1
1
62.5
ticagrelor measurement
1
1
1
36.5
dehydroepiandrosterone sulphate measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
78.3
reticulocyte measurement
2
63.1
FEV/FEC ratio
1
62.5
ticagrelor measurement
1
36.5
dehydroepiandrosterone sulphate measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stromal antigen 3
VGNC:8764
463593
Macaque
stromal antigen 3
711345
Mouse
MGI:1355311
50878
Rat
RGD:621333
114522
Dog
stromal antigen 3
VGNC:54072
489842
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stromal antigen 3
Macaque
stromal antigen 3
Mouse
Rat
Dog
stromal antigen 3
Publication Statistics
PubMed Score 34.26
PubMed score by year
PubTator Score 14.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title