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Tbio
CD207
C-type lectin domain family 4 member K

Protein Summary
Description
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000410009
  • ENSP00000386378
  • ENSG00000116031

Symbol
  • CLEC4K
  • CLEC4K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.8
gene perturbation
0.71
protein domain
0.58
cell type or tissue
0.57
PubMedID
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.87   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.87   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.99999961
p_ni:  3.78e-7
p_wrong:  1.2e-8
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.999997434
p_ni:  0.000002554
p_wrong:  1.2e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
SUSD3
Tdark
Novelty:  0.43699506
p_int:  0.999877063
p_ni:  0.000011973
p_wrong:  0.000110964
Score:  0.211
Data Source:  BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999874966
p_ni:  0.000036523
p_wrong:  0.000088511
Score:  0.201
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.766509646
p_ni:  0.000032297
p_wrong:  0.233458056
Data Source:  BioPlex
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.943
Data Source:  STRINGDB
MRC1
Tbio
Novelty:  0.00104675
Score:  0.922
Data Source:  STRINGDB
FCGR1B
Tbio
Novelty:  0.01365788
Score:  0.906
Data Source:  STRINGDB
MRC2
Tbio
Novelty:  0.01100289
Score:  0.905
Data Source:  STRINGDB
CD1C
Tbio
Novelty:  0.00089865
Score:  0.875
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cross-presentation of soluble exogenous antigens (endosomes)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cross-presentation of soluble exogenous antigens (endosomes)
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
26.6
influenza A (H1N1)
1
1
0
19.4
7.6
1
1
0
1.1
1.9
gut microbiome measurement
1
1
0
5.6
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
26.6
influenza A (H1N1)
0
19.4
7.6
0
1.1
1.9
gut microbiome measurement
0
5.6
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD207 molecule
VGNC:187
737419
Macaque
CD207 molecule
703420
Mouse
MGI:2180021
246278
Rat
RGD:1565913
502852
Dog
CD207 molecule
VGNC:54285
612679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD207 molecule
Macaque
CD207 molecule
Mouse
Rat
Dog
CD207 molecule
Publication Statistics
PubMed Score 370.87
PubMed score by year
PubTator Score 156.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title