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Tbio
NAGK
N-acetyl-D-glucosamine kinase

Protein Summary
Description
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity. This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244204
  • ENSP00000244204
  • ENSG00000124357
  • ENST00000455662
  • ENSP00000389087
  • ENST00000613852
  • ENSP00000477639

Symbol
  • GNK
  • HSA242910
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
molecular function
0.93
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.6   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.6   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of UDP-N-acetyl-glucosamine
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of UDP-N-acetyl-glucosamine
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (88)
1 – 10 of 88
ZBTB43
Tdark
Family: TF
Novelty: 0.35735342
p_int: 0.99999985
p_ni: 1.04e-7
p_wrong: 4.6e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
RAI1
Tbio
Family: Epigenetic
Novelty: 0.01088494
p_int: 0.999999741
p_ni: 3.5e-8
p_wrong: 2.25e-7
Score: 0.356
Data Source: BioPlex,STRINGDB
HOXB6
Tbio
Family: TF
Novelty: 0.0176813
p_int: 0.999997302
p_ni: 4.14e-7
p_wrong: 0.000002284
Score: 0.189
Data Source: BioPlex,STRINGDB
RBM6
Tbio
Novelty: 0.06349982
p_int: 0.999996294
p_ni: 0.000003705
p_wrong: 1e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
SCAF8
Tbio
Novelty: 0.1650699
p_int: 0.999988614
p_ni: 0.000011386
Score: 0.181
Data Source: BioPlex,STRINGDB
ZIC2
Tbio
Family: TF
Novelty: 0.00900257
p_int: 0.999969558
p_ni: 0.000004537
p_wrong: 0.000025905
Score: 0.186
Data Source: BioPlex,STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
p_int: 0.998952295
p_ni: 0.001047705
Score: 0.186
Data Source: BioPlex,STRINGDB
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.99876885
p_ni: 0.001231149
p_wrong: 1e-9
Data Source: BioPlex
XRN1
Tbio
Family: Enzyme
Novelty: 0.00409381
p_int: 0.998429126
p_ni: 0.001551415
p_wrong: 0.000019459
Score: 0.181
Data Source: BioPlex,STRINGDB
C2CD5
Tbio
Novelty: 0.40144687
p_int: 0.997133095
p_ni: 0.002866891
p_wrong: 1.5e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  61.60

PubMed score by year
PubTator Score  24.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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