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Tbio
MSRA
Mitochondrial peptide methionine sulfoxide reductase

Protein Summary
Description
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317173
  • ENSP00000313921
  • ENSG00000175806
  • ENST00000382490
  • ENSP00000371930
  • ENST00000441698
  • ENSP00000410912
  • ENST00000528246
  • ENSP00000436839
  • ENST00000643047
  • ENSP00000493922
  • ENSG00000285250
  • ENST00000643332
  • ENSP00000495223
  • ENST00000645254
  • ENSP00000496174
  • ENST00000645318
  • ENSP00000493848

Symbol
  • PMSR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
trait
0.97
disease perturbation
0.87
transcription factor binding site profile
0.76
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.71   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.71   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
p_int:  0.999998758
p_ni:  1e-8
p_wrong:  0.000001232
Score:  0.397
Data Source:  BioPlex,STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
p_int:  0.997287135
p_ni:  0.000242387
p_wrong:  0.002470477
Score:  0.309
Data Source:  BioPlex,STRINGDB
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.92868882
p_ni:  1.38e-7
p_wrong:  0.071311042
Score:  0.239
Data Source:  BioPlex,STRINGDB
MSRB2
Tbio
Family:  Enzyme
Novelty:  0.00729088
Score:  0.993
Data Source:  STRINGDB
MSRB3
Tbio
Family:  Enzyme
Novelty:  0.02843512
Score:  0.991
Data Source:  STRINGDB
TXN
Tchem
Novelty:  0.00048949
Score:  0.986
Data Source:  Reactome,STRINGDB
MSRB1
Tbio
Family:  Enzyme
Novelty:  0.01677161
Score:  0.907
Data Source:  STRINGDB
RP1L1
Tbio
Novelty:  0.02385711
Score:  0.904
Data Source:  STRINGDB
SOX7
Tbio
Family:  TF
Novelty:  0.01269127
Score:  0.801
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.788
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Latent infection - Other responses of Mtb to phagocytosis
Reactome
Metabolism of proteins
Reactome
Protein repair
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Latent infection - Other responses of Mtb to phagocytosis
Metabolism of proteins
Protein repair
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (94)
Items per page:
1 – 5 of 94
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
43
40
6.2
96.7
neuroticism measurement
4
43
40
6.2
96.7
triglyceride measurement
2
3
3
93.7
triglyceride measurement
2
3
3
93.7
mathematical ability
3
5
6
92.8
Items per page:
1 – 5 of 94
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
40
6.2
96.7
neuroticism measurement
40
6.2
96.7
triglyceride measurement
3
93.7
triglyceride measurement
3
93.7
mathematical ability
6
92.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methionine sulfoxide reductase A
VGNC:13186
739556
Macaque
methionine sulfoxide reductase A
698628
Mouse
MGI:106916
110265
Rat
RGD:70979
29447
Dog
methionine sulfoxide reductase A
VGNC:43449
608103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methionine sulfoxide reductase A
Macaque
methionine sulfoxide reductase A
Mouse
Rat
Dog
methionine sulfoxide reductase A
Publication Statistics
PubMed Score 179.71
PubMed score by year
PubTator Score 146.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title