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Tbio
RABGEF1
Rab5 GDP/GTP exchange factor

Protein Summary
Description
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284957
  • ENSP00000284957
  • ENSG00000154710
  • ENST00000380828
  • ENSP00000370208
  • ENST00000450873
  • ENSP00000415815

Symbol
  • RABEX5
  • RAP1
  • RABEX5
  • rabex-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
histone modification site profile
0.84
molecular function
0.84
virus perturbation
0.83
transcription factor binding site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.25   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.25   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
3.2
57.8
glomerular filtration rate
2
2
2
50.4
cotinine glucuronidation measurement
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3.2
57.8
glomerular filtration rate
2
50.4
cotinine glucuronidation measurement
1
2.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB guanine nucleotide exchange factor 1
VGNC:8742
463453
Macaque
RAB guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:17676]
Mouse
MGI:1929459
56715
Rat
RGD:1307295
360797
Dog
RAB guanine nucleotide exchange factor 1
VGNC:54062
479706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB guanine nucleotide exchange factor 1
Macaque
RAB guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:17676]
Mouse
Rat
Dog
RAB guanine nucleotide exchange factor 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UJ41-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (178)
1 – 10 of 178
RABEP2
Tbio
Family:  Enzyme
Novelty:  0.18180682
p_int:  0.999999998
p_ni:  2e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
RABEP1
Tbio
Family:  Enzyme
Novelty:  0.02318446
p_int:  0.99999999
p_ni:  1.1e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.999996296
p_ni:  0.000003688
p_wrong:  1.6e-8
Data Source:  BioPlex
CPNE5
Tbio
Novelty:  0.09416684
p_int:  0.999980347
p_ni:  0.000019653
Data Source:  BioPlex
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999976767
p_ni:  0.000023233
Score:  0.228
Data Source:  BioPlex,STRINGDB
RBCK1
Tbio
Novelty:  0.02760333
p_int:  0.999756934
p_ni:  0.000243048
p_wrong:  1.7e-8
Score:  0.428
Data Source:  BioPlex,STRINGDB
OTUD5
Tbio
Novelty:  0.0498487
p_int:  0.999751668
p_ni:  0.000056063
p_wrong:  0.000192269
Score:  0.265
Data Source:  BioPlex,STRINGDB
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.999671889
p_ni:  0.000300425
p_wrong:  0.000027686
Score:  0.67
Data Source:  BioPlex,STRINGDB
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.999621453
p_ni:  0.000378547
Score:  0.155
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999597208
p_ni:  0.000402787
p_wrong:  6e-9
Score:  0.279
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  40.25

PubMed score by year
PubTator Score  55.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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