Tbio ST6GALNAC2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Protein Summary

Description

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins. ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9UJ37
• Q12971

Gene Name

• ST6GALNAC2

Ensembl ID

• ENST00000225276
• ENSP00000225276
• ENSG00000070731

Symbol

• SIAT7B
• SIATL1
• STHM
• STHM
• SIAT7
• SAITL1
• SIAT7B
• SIATL1
• ST6GalNAII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
PubMedID	0.91
disease perturbation	0.87
histone modification site profile	0.77
tissue sample	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.3   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 78   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.3   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0