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Tbio
ST6GALNAC2
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Protein Summary
Description
Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins. ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225276
  • ENSP00000225276
  • ENSG00000070731

Symbol
  • SIAT7B
  • SIATL1
  • STHM
  • STHM
  • SIAT7
  • SAITL1
  • SIAT7B
  • SIATL1
  • ST6GalNAII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
PubMedID
0.91
disease perturbation
0.87
histone modification site profile
0.77
tissue sample
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.32   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.32   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
64.9
eosinophil count
2
1
2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
64.9
eosinophil count
2
44.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
VGNC:9661
449513
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
707237
Mouse
MGI:107553
20446
Rat
RGD:1560747
303692
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
VGNC:54367
100049005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Mouse
Rat
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UJ37-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Protein-Protein Interactions (100)
1 – 10 of 100
MUC1
Tchem
Novelty:  0.00024203
Score:  0.945
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.932
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.928
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.923
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.919
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.915
Data Source:  STRINGDB
MUC20
Tbio
Novelty:  0.04645313
Score:  0.915
Data Source:  STRINGDB
MUC17
Tbio
Novelty:  0.03624836
Score:  0.913
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.912
Data Source:  STRINGDB
MUC12
Tbio
Novelty:  0.04323645
Score:  0.91
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.32

PubMed score by year
PubTator Score  17.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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