You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PLXNA1
Plexin-A1

Protein Summary
Description
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393409
  • ENSP00000377061
  • ENSG00000114554

Symbol
  • NOV
  • PLXN1
  • NOV
  • NOVP
  • PLXN1
  • PLEXIN-A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.83
protein complex
0.81
transcription factor perturbation
0.8
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.54   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.54   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.983497175
p_ni:  0.016502825
Data Source:  BioPlex
IFI35
Tbio
Novelty:  0.04309126
p_int:  0.980820112
p_ni:  0.019179888
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.965000575
p_ni:  0.034999426
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.953357932
p_ni:  0.046642068
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.953278999
p_ni:  0.046721001
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.949195802
p_ni:  0.050804198
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.94231959
p_ni:  0.057680409
p_wrong:  1e-9
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.92983065
p_ni:  0.07016935
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.874889744
p_ni:  0.125110256
Data Source:  BioPlex
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.846781268
p_ni:  0.153218732
Score:  0.201
Data Source:  BioPlex,STRINGDB
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
Other semaphorin interactions
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plexin A1
VGNC:2516
460665
Macaque
plexin A1
716805
Mouse
MGI:107685
18844
Rat
RGD:1560871
362398
Dog
plexin A1
VGNC:44718
100688869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plexin A1
Macaque
plexin A1
Mouse
Rat
Dog
plexin A1
Publication Statistics
PubMed Score 77.54
PubMed score by year
PubTator Score 35.53
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title