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Tbio
PLXNA1
Plexin-A1

Protein Summary
Description
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393409
  • ENSP00000377061
  • ENSG00000114554

Symbol
  • NOV
  • PLXN1
  • NOV
  • NOVP
  • PLXN1
  • PLEXIN-A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.83
protein complex
0.81
transcription factor perturbation
0.8
disease perturbation
0.79


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.48   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.48   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plexin A1
VGNC:2516
460665
Macaque
plexin A1
716805
Mouse
MGI:107685
18844
Rat
RGD:1560871
362398
Dog
plexin A1
VGNC:44718
100688869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plexin A1
Macaque
plexin A1
Mouse
Rat
Dog
plexin A1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UIW2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
Other semaphorin interactions
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (136)
1 – 10 of 136
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.983497175
p_ni: 0.016502825
Data Source: BioPlex
IFI35
Tbio
Novelty: 0.04309126
p_int: 0.980820112
p_ni: 0.019179888
Data Source: BioPlex
OS9
Tbio
Novelty: 0.01490339
p_int: 0.965000575
p_ni: 0.034999426
Data Source: BioPlex
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.953357932
p_ni: 0.046642068
Data Source: BioPlex
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.953278999
p_ni: 0.046721001
Data Source: BioPlex
SCGB1D1
Tbio
Novelty: 0.04199997
p_int: 0.949195802
p_ni: 0.050804198
Data Source: BioPlex
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.94231959
p_ni: 0.057680409
p_wrong: 1e-9
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.92983065
p_ni: 0.07016935
Data Source: BioPlex
MSMB
Tbio
Novelty: 0.00241546
p_int: 0.874889744
p_ni: 0.125110256
Data Source: BioPlex
MGAT4C
Tdark
Family: Enzyme
Novelty: 0.19680806
p_int: 0.846781268
p_ni: 0.153218732
Score: 0.201
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  74.48

PubMed score by year
PubTator Score  35.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer