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Tbio
MBD1
Methyl-CpG-binding domain protein 1

Protein Summary
Description
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269468
  • ENSP00000269468
  • ENSG00000141644
  • ENST00000269471
  • ENSP00000269471
  • ENST00000339998
  • ENSP00000339546
  • ENST00000347968
  • ENSP00000285102
  • ENST00000353909
  • ENSP00000269469
  • ENST00000382948
  • ENSP00000372407
  • ENST00000398488
  • ENSP00000381502
  • ENST00000398493
  • ENSP00000381506
  • ENST00000457839
  • ENSP00000405268
  • ENST00000585595
  • ENSP00000468430
  • ENST00000585672
  • ENSP00000466092
  • ENST00000587605
  • ENSP00000468042
  • ENST00000588937
  • ENSP00000467763
  • ENST00000590208
  • ENSP00000468785
  • ENST00000591416
  • ENSP00000467017
  • ENST00000591535
  • ENSP00000465923

Symbol
  • CXXC3
  • PCM1
  • RFT
  • PCM1
  • CXXC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.91
disease perturbation
0.79
molecular function
0.79
microRNA
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.32   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 372   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.32   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.955
Data Source:  Reactome,STRINGDB
PIAS1
Tbio
Family:  TF
Novelty:  0.00987743
Score:  0.943
Data Source:  STRINGDB
PIAS3
Tbio
Family:  TF
Novelty:  0.01380668
Score:  0.937
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.9
Data Source:  Reactome,STRINGDB
ATF7IP
Tbio
Novelty:  0.04269323
Score:  0.768
Data Source:  STRINGDB
LIX1
Tbio
Novelty:  0.03028158
Score:  0.763
Data Source:  STRINGDB
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
Score:  0.706
Data Source:  STRINGDB
TENM1
Tbio
Novelty:  0.01770087
Score:  0.642
Data Source:  STRINGDB
CBX5
Tbio
Family:  Epigenetic
Novelty:  0.00653413
Score:  0.593
Data Source:  STRINGDB
MBD4
Tbio
Family:  TF
Novelty:  0.00876432
Score:  0.578
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription cofactors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
49.5
1
1
0
1.1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
49.5
0
1.1
3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyl-CpG binding domain protein 1
VGNC:5182
455418
Macaque
methyl-CpG binding domain protein 1
709798
Mouse
MGI:1333811
17190
Rat
RGD:1305980
291439
Dog
methyl-CpG binding domain protein 1
VGNC:43049
480218
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyl-CpG binding domain protein 1
Macaque
methyl-CpG binding domain protein 1
Mouse
Rat
Dog
methyl-CpG binding domain protein 1
Publication Statistics
PubMed Score 44.32
PubMed score by year
PubTator Score 68.47
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title