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Tbio
BTNL2
Butyrophilin-like protein 2

Protein Summary
Description
Negative regulator of T-cell proliferation. This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374993
  • ENSP00000364132
  • ENSG00000204290
  • ENST00000544175
  • ENSP00000443364
  • ENST00000548253
  • ENSP00000447733
  • ENSG00000224242
  • ENST00000548717
  • ENSP00000449356
  • ENSG00000225412
  • ENST00000548832
  • ENSP00000448852
  • ENSG00000229741
  • ENST00000549560
  • ENSP00000448550
  • ENSG00000226127
  • ENST00000549852
  • ENSP00000446915
  • ENSG00000225845
  • ENST00000549943
  • ENSP00000449578
  • ENSG00000224770
  • ENST00000550327
  • ENSP00000447985
  • ENST00000550531
  • ENSP00000448023
  • ENSG00000229597
  • ENST00000550698
  • ENSP00000447616
  • ENST00000551095
  • ENSP00000449546
  • ENST00000551669
  • ENSP00000446794
  • ENST00000551686
  • ENSP00000450139
  • ENST00000552479
  • ENSP00000449365
  • ENST00000553032
  • ENSP00000447291

Symbol
  • SS2
  • BTN7
  • BTL-II
  • HSBLMHC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
disease
0.76
phenotype
0.75
protein domain
0.73
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 611   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 611   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
P04229
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
P13761
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
P01911
Tchem
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
P20039
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
Q5Y7A7
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
Q30167
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
Q9TQE0
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
Q30134
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
P01912
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
P13760
Tbio
Novelty:  0.00240724
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (840)
Items per page:
1 – 5 of 840
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
3
2.3
99.6
8
8
3
2.3
99.6
8
8
3
2.3
99.6
8
8
3
2.3
99.6
8
8
3
2.3
99.6
Items per page:
1 – 5 of 840
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2.3
99.6
3
2.3
99.6
3
2.3
99.6
3
2.3
99.6
3
2.3
99.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1859549
547431
Rat
RGD:620731
309620
Dog
butyrophilin like 2
481730
Horse
butyrophilin like 2
VGNC:49275
100051881
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
butyrophilin like 2
Horse
butyrophilin like 2
Publication Statistics
PubMed Score 611.00
PubMed score by year
PubTator Score 129.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title