BTNL2
Butyrophilin-like protein 2
Protein Summary
Negative regulator of T-cell proliferation. This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]
- ENST00000374993
- ENSP00000364132
- ENSG00000204290
- ENST00000544175
- ENSP00000443364
- ENST00000548253
- ENSP00000447733
- ENSG00000224242
- ENST00000548717
- ENSP00000449356
- ENSG00000225412
- ENST00000548832
- ENSP00000448852
- ENSG00000229741
- ENST00000549560
- ENSP00000448550
- ENSG00000226127
- ENST00000549852
- ENSP00000446915
- ENSG00000225845
- ENST00000549943
- ENSP00000449578
- ENSG00000224770
- ENST00000550327
- ENSP00000447985
- ENST00000550531
- ENSP00000448023
- ENSG00000229597
- ENST00000550698
- ENSP00000447616
- ENST00000551095
- ENSP00000449546
- ENST00000551669
- ENSP00000446794
- ENST00000551686
- ENSP00000450139
- ENST00000552479
- ENSP00000449365
- ENST00000553032
- ENSP00000447291
- SS2
- BTN7
- BTL-II
- HSBLMHC1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
disease | 0.76 | ||
phenotype | 0.75 | ||
protein domain | 0.73 | ||
tissue | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.54 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 120 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.54 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 120 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0