Tchem LNPEP Leucyl-cystinyl aminopeptidase

Protein Summary

Description

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UIQ6
• O00769
• Q15145
• Q59H76
• Q9TNQ2
• Q9TNQ3
• Q9UIQ7
• Cystinyl aminopeptidase

Gene Name

• LNPEP

Ensembl ID

• ENST00000231368
• ENSP00000231368
• ENSG00000113441
• ENST00000395770
• ENSP00000379117

Symbol

• OTASE
• CAP
• IRAP
• PLAP
• P-LAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor binding site profile	0.98
transcription factor perturbation	0.91
histone modification site profile	0.87
small molecule perturbation	0.75

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Leucyl-cystinyl Aminopeptidase

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Leucyl-cystinyl Aminopeptidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.37   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.37   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0