Tchem DAPK2 Death-associated protein kinase 2

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Death-associated Protein Kinase 2

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Dapk Family / Death-associated Protein Kinase 2

Protein Summary

Description

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UIK4
• E9JGM7
• O75892
• Q24JS1
• DAP kinase 2

Gene Name

• DAPK2

Ensembl ID

• ENST00000261891
• ENSP00000261891
• ENSG00000035664
• ENST00000457488
• ENSP00000408277
• ENST00000558069
• ENSP00000453235
• ENST00000612884
• ENSP00000484390

Symbol

• DRP1
• DRP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
co-expressed gene	0.91
disease perturbation	0.9
protein domain	0.85
histone modification site profile	0.84

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.97   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 564   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.97   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

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1 – 1 of 1

fedratinib

DAPK2Tchem Kinase

Kd: 7.54

Active Ligands (2)

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1 – 2 of 2

CHEMBL388978

DAPK2Tchem Kinase

Kd: 8.8

CHEMBL3103192

DAPK2Tchem Kinase

IC50: 8

Protein Data Bank (8)

1 – 5 of 8

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (8)

Reactome (4)

KEGG (3)

WikiPathways (1)

Apoptosis (R-HSA-109581)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Caspase activation via Dependence Receptors in the absence of ligand	10 targets	R-HSA-418889
Reactome	Caspase activation via extrinsic apoptotic signalling pathway	26 targets	R-HSA-5357769
Reactome	Programmed Cell Death	180 targets	R-HSA-5357801

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Caspase activation via Dependence Receptors in the absence of ligand	10 targets	R-HSA-418889
Caspase activation via extrinsic apoptotic signalling pathway	26 targets	R-HSA-5357769
Programmed Cell Death	180 targets	R-HSA-5357801

Gene Ontology Terms (21)

Functions (4)

Components (6)

Processes (11)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
calmodulin binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein serine/threonine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (26)

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1 – 10 of 26

• See Interactions on String-DB

CALM1

Tclin

Novelty: 0.00308267

Score: 0.958

Data Source: STRINGDB

CALM2

Tclin

Novelty: 0.01876254

Score: 0.958

Data Source: STRINGDB

CALM3

Tclin

Novelty: 0.00461552

Score: 0.958

Data Source: STRINGDB

UNC5B

Tbio

Novelty: 0.01474065

Score: 0.941

Data Source: STRINGDB

CASP3

Tchem

Family: Enzyme

Novelty: 0.00003555

Score: 0.922

Data Source: STRINGDB

MAPK3

Tchem

Family: Kinase

Novelty: 0.00012969

Score: 0.857

Data Source: STRINGDB

MAPK1

Tchem

Family: Kinase

Novelty: 0.00061058

Score: 0.851

Data Source: STRINGDB

BECN1

Tbio

Novelty: 0.0003792

Score: 0.83

Data Source: STRINGDB

DAPK3

Tchem

Family: Kinase

Novelty: 0.01551494

Score: 0.807

Data Source: STRINGDB

DAPK1

Tchem

Family: Kinase

Novelty: 0.0031894

Score: 0.803

Data Source: STRINGDB

Publication Statistics

PubMed Score  45.97

PubMed score by year

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PubTator Score  34.4

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

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Structural Annotations

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Apoptosis
ATP-binding
Calmodulin-binding
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Kinase
Nucleotide-binding

MGI Phenotype Find Similar Targets

homeostasis/metabolism phenotype