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Tchem
DAPK2
Death-associated protein kinase 2

Protein Summary
Description
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261891
  • ENSP00000261891
  • ENSG00000035664
  • ENST00000457488
  • ENSP00000408277
  • ENST00000558069
  • ENSP00000453235
  • ENST00000612884
  • ENSP00000484390

Symbol
  • DRP1
  • DRP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
co-expressed gene
0.91
disease perturbation
0.9
protein domain
0.85
histone modification site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.97   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 564   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.97   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
fedratinib
chemical structure image
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Programmed Cell Death
Protein-Protein Interactions (26)
1 – 10 of 26
CALM1
Tclin
Novelty: 0.00308267
Score: 0.958
Data Source: STRINGDB
CALM2
Tclin
Novelty: 0.01876254
Score: 0.958
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.958
Data Source: STRINGDB
UNC5B
Tbio
Novelty: 0.01474065
Score: 0.941
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.922
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.857
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.851
Data Source: STRINGDB
BECN1
Tbio
Novelty: 0.0003792
Score: 0.83
Data Source: STRINGDB
DAPK3
Tchem
Family: Kinase
Novelty: 0.01551494
Score: 0.807
Data Source: STRINGDB
DAPK1
Tchem
Family: Kinase
Novelty: 0.0031894
Score: 0.803
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.97

PubMed score by year
PubTator Score  34.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer