Tchem DAPK2 Death-associated protein kinase 2

Protein Summary

Description

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UIK4
• E9JGM7
• O75892
• Q24JS1
• DAP kinase 2

Gene Name

• DAPK2

Ensembl ID

• ENST00000261891
• ENSP00000261891
• ENSG00000035664
• ENST00000457488
• ENSP00000408277
• ENST00000558069
• ENSP00000453235
• ENST00000612884
• ENSP00000484390

Symbol

• DRP1
• DRP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
co-expressed gene	0.91
disease perturbation	0.9
protein domain	0.85
histone modification site profile	0.84

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Death-associated Protein Kinase 2

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Dapk Family / Death-associated Protein Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.06   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 564   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.06   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1