DAPK2
Death-associated protein kinase 2
Protein Summary
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmod ...more
- ENST00000261891
- ENSP00000261891
- ENSG00000035664
- ENST00000457488
- ENSP00000408277
- ENST00000558069
- ENSP00000453235
- ENST00000612884
- ENSP00000484390
- DRP1
- DRP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.95 | ||
co-expressed gene | 0.91 | ||
disease perturbation | 0.9 | ||
protein domain | 0.85 | ||
histone modification site profile | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.91 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 564 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.91 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 564 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (2)
Protein-Protein Interactions (26)
Nearest Tclin Targets (4)
Downstream (4)
1 – 4 of 4
Pathways (8)
Reactome (4)
KEGG (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Caspase activation via Dependence Receptors in the absence of ligand | ||||
Reactome | Caspase activation via extrinsic apoptotic signalling pathway | ||||
Reactome | Programmed Cell Death | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Caspase activation via Dependence Receptors in the absence of ligand | ||||
Caspase activation via extrinsic apoptotic signalling pathway | ||||
Programmed Cell Death | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (4)
Components (6)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein B measurement | 1 | 1 | 1 | 35 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 17.6 | |||||
red blood cell distribution width | 2 | 1 | 2 | 17.5 | |||||
1 | 1 | 0 | 1 | 14.2 | |||||
BMI-adjusted waist circumference | 1 | 1 | 1 | 5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein B measurement | 1 | 35 | |||||
high density lipoprotein cholesterol measurement | 1 | 17.6 | |||||
red blood cell distribution width | 2 | 17.5 | |||||
0 | 1 | 14.2 | |||||
BMI-adjusted waist circumference | 1 | 5 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | death associated protein kinase 2 | VGNC:11853 | 747631 | |||||
Macaque | death associated protein kinase 2 | 706421 | ||||||
Mouse | MGI:1341297 | 13143 | ||||||
Horse | death associated protein kinase 2 | VGNC:17007 | 100066921 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | death associated protein kinase 2 | |||||
Macaque | death associated protein kinase 2 | |||||
Mouse | ||||||
Horse | death associated protein kinase 2 | |||||
Publication Statistics
PubMed Score 48.91
PubMed score by year
PubTator Score 34.40
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (33)
GeneRif Annotations (23)
Items per page:
0 of 0
PMID | Year | Title |
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