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Tbio
AK3
GTP:AMP phosphotransferase AK3, mitochondrial

Protein Summary
Description
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359883
  • ENSP00000352948
  • ENSG00000147853
  • ENST00000381809
  • ENSP00000371230
  • ENST00000447596
  • ENSP00000413933
  • ENST00000611749
  • ENSP00000482308

Symbol
  • AK3L1
  • AK6
  • AKL3L
  • AK6
  • FIX
  • AK3L1
  • AKL3L
  • AKL3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.88
small molecule perturbation
0.87
PubMedID
0.86
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.41   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 347   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.41   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0