AK3
GTP:AMP phosphotransferase AK3, mitochondrial
Protein Summary
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
- ENST00000359883
- ENSP00000352948
- ENSG00000147853
- ENST00000381809
- ENSP00000371230
- ENST00000447596
- ENSP00000413933
- ENST00000611749
- ENSP00000482308
- AK3L1
- AK6
- AKL3L
- AK6
- FIX
- AK3L1
- AKL3L
- AKL3L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.87 | ||
PubMedID | 0.86 | ||
transcription factor binding site profile | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.41 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 347 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.41 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 347 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0