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Tbio
HERC5
E3 ISG15--protein ligase HERC5

Protein Summary
Description
Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. This gene is a member of the HERC family of ubiquitin ligases ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264350
  • ENSP00000264350
  • ENSG00000138646

Symbol
  • CEB1
  • CEBP1
  • CEB1
  • CEBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.71
histone modification site profile
0.7
tissue sample
0.7
small molecule perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.66   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.66   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
2
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
56.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT and RLD domain containing E3 ubiquitin protein ligase 5
VGNC:610
461369
Macaque
HECT and RLD domain containing E3 ubiquitin protein ligase 5
702743
Horse
HECT and RLD domain containing E3 ubiquitin protein ligase 5
VGNC:18753
100063774
Cow
HECT and RLD domain containing E3 ubiquitin protein ligase 5
VGNC:29814
514373
Anole lizard
probable E3 ubiquitin-protein ligase HERC6
100568112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT and RLD domain containing E3 ubiquitin protein ligase 5
Macaque
HECT and RLD domain containing E3 ubiquitin protein ligase 5
Horse
HECT and RLD domain containing E3 ubiquitin protein ligase 5
Cow
HECT and RLD domain containing E3 ubiquitin protein ligase 5
Anole lizard
probable E3 ubiquitin-protein ligase HERC6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UII4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Antiviral mechanism by IFN-stimulated genes
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (353)
1 – 10 of 353
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.999330711
p_ni:  0.000669289
Data Source:  BioPlex
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.980004828
p_ni:  0.019995172
Data Source:  BioPlex
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.978266812
p_ni:  0.021733187
Data Source:  BioPlex
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.975667037
p_ni:  0.024332963
Data Source:  BioPlex
NOP16
Tdark
Novelty:  0.27480251
p_int:  0.96778687
p_ni:  0.03221313
Score:  0.241
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.937649753
p_ni:  0.062350247
Score:  0.236
Data Source:  BioPlex,STRINGDB
RPL14
Tbio
Novelty:  0.01600377
p_int:  0.920915852
p_ni:  0.079084148
Data Source:  BioPlex
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.890206171
p_ni:  0.109793829
Data Source:  BioPlex
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.887979764
p_ni:  0.112020236
Data Source:  BioPlex
CCDC59
Tbio
Novelty:  0.05894885
p_int:  0.873112485
p_ni:  0.126887515
Score:  0.176
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  60.66

PubMed score by year
PubTator Score  45.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer