You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KLF15
Krueppel-like factor 15

Protein Summary
Description
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296233
  • ENSP00000296233
  • ENSG00000163884

Symbol
  • KKLF
  • KKLF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
biological process
0.88
microRNA
0.7
molecular function
0.67
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.04   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.04   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
2
2
99.1
1
1
1
60.7
Alopecia
1
2
2
59.3
lymphoid leukemia
1
1
0
2.1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
99.1
1
60.7
Alopecia
2
59.3
lymphoid leukemia
0
2.1
3.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 15
VGNC:53368
470911
Macaque
Kruppel like factor 15
716386
Mouse
MGI:1929988
66277
Rat
RGD:70918
85497
Dog
Kruppel like factor 15
VGNC:42434
609067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 15
Macaque
Kruppel like factor 15
Mouse
Rat
Dog
Kruppel like factor 15
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UIH9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (51)
1 – 10 of 51
VWA2
Tbio
Novelty: 0.05840015
p_int: 0.994392347
p_ni: 0.005607643
p_wrong: 1.1e-8
Score: 0.269
Data Source: BioPlex,STRINGDB
PPP2R5E
Tbio
Family: Enzyme
Novelty: 0.05974697
p_int: 0.987784128
p_ni: 0.012215872
Score: 0.237
Data Source: BioPlex,STRINGDB
ADD3
Tbio
Family: Enzyme
Novelty: 0.02164464
p_int: 0.887969394
p_ni: 0.111993819
p_wrong: 0.000036788
Score: 0.345
Data Source: BioPlex,STRINGDB
ARNTL
Tbio
Family: TF
Novelty: 0.00102829
Score: 0.943
Data Source: STRINGDB
NPAS2
Tbio
Family: TF
Novelty: 0.00728451
Score: 0.925
Data Source: STRINGDB
CLOCK
Tbio
Family: TF; Epigenetic
Novelty: 0.00159625
Score: 0.925
Data Source: STRINGDB
CFAP100
Tbio
Novelty: 0.11194637
Score: 0.801
Data Source: STRINGDB
PODXL2
Tbio
Novelty: 0.09100487
Score: 0.8
Data Source: STRINGDB
TMCC1
Tbio
Novelty: 0.13345982
Score: 0.8
Data Source: STRINGDB
BCAT2
Tchem
Family: Enzyme
Novelty: 0.00885158
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  129.04

PubMed score by year
PubTator Score  38.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: