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Tbio
SLCO3A1
Solute carrier organic anion transporter family member 3A1

Protein Summary
Description
Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318445
  • ENSP00000320634
  • ENSG00000176463
  • ENST00000424469
  • ENSP00000387846

Symbol
  • OATP3A1
  • OATPD
  • SLC21A11
  • OATPD
  • OATP-D
  • OATP3A1
  • OATPRP3
  • OATP-RP3
  • SLC21A11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor perturbation
0.98
trait
0.86
microRNA
0.85
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.74   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.74   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
73.9
waist-hip ratio
1
1
1
67
diastolic blood pressure
1
1
1
38.5
body height
1
1
1
16.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
73.9
waist-hip ratio
1
67
diastolic blood pressure
1
38.5
body height
1
16.9
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of organic anions
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of organic anions
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Protein-Protein Interactions (39)
1 – 10 of 39
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.00357766
Score: 0.72
Data Source: STRINGDB
SLC7A13
Tdark
Family: Transporter
Novelty: 0.20907223
Score: 0.705
Data Source: STRINGDB
SLC16A10
Tbio
Family: Transporter
Novelty: 0.02363735
Score: 0.633
Data Source: STRINGDB
SLC16A2
Tbio
Family: Transporter
Novelty: 0.00353339
Score: 0.628
Data Source: STRINGDB
SLC22A8
Tclin
Family: Transporter
Novelty: 0.00291642
Score: 0.623
Data Source: STRINGDB
SLC22A11
Tclin
Family: Transporter
Novelty: 0.01343595
Score: 0.607
Data Source: STRINGDB
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02212992
Score: 0.581
Data Source: STRINGDB
SLC15A2
Tchem
Family: Transporter
Novelty: 0.00573108
Score: 0.564
Data Source: STRINGDB
PTH1R
Tclin
Family: GPCR
Novelty: 0.00413989
Score: 0.561
Data Source: STRINGDB
CRLS1
Tbio
Family: Enzyme
Novelty: 0.08214782
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.74

PubMed score by year
PubTator Score  17.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer