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Tbio
BAZ1B
Tyrosine-protein kinase BAZ1B

Protein Summary
Description
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. This gene encodes a member of the bromodomain protein family. The bromodomai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339594
  • ENSP00000342434
  • ENSG00000009954
  • ENST00000404251
  • ENSP00000385442

Symbol
  • WBSC10
  • WBSCR10
  • WBSCR9
  • WSTF
  • WSTF
  • WBSCR9
  • WBSCR10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
co-expressed gene
0.94
transcription factor binding site profile
0.89
drug perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.53   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.53   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
10
9
15
98.9
sleep duration
2
3
3
79.2
urate measurement
2
1
2
71.8
high density lipoprotein cholesterol measurement
1
1
2
70
metabolic syndrome
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
15
98.9
sleep duration
3
79.2
urate measurement
2
71.8
high density lipoprotein cholesterol measurement
2
70
metabolic syndrome
1
66.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
bromodomain adjacent to zinc finger domain 1B
716436
Mouse
MGI:1353499
22385
Rat
RGD:1597089
368002
Dog
bromodomain adjacent to zinc finger domain 1B
VGNC:38390
479719
Horse
bromodomain adjacent to zinc finger domain 1B
VGNC:15774
100061668
Species
Name
OMA
EggNOG
Inparanoid
Macaque
bromodomain adjacent to zinc finger domain 1B
Mouse
Rat
Dog
bromodomain adjacent to zinc finger domain 1B
Horse
bromodomain adjacent to zinc finger domain 1B
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UIG0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Epigenetic regulation of gene expression
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (179)
1 – 10 of 179
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.999956701
p_ni: 0.000043299
p_wrong: 1e-9
Score: 0.225
Data Source: BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty: 0.01357759
p_int: 0.999349667
p_ni: 0.000279676
p_wrong: 0.000370657
Score: 0.211
Data Source: BioPlex,STRINGDB
SMARCA5
Tbio
Novelty: 0.00518484
Score: 0.999
Data Source: Reactome,STRINGDB
SMARCA4
Tchem
Family: Epigenetic
Novelty: 0.00112496
Score: 0.993
Data Source: STRINGDB
SMARCC1
Tbio
Family: TF; Epigenetic
Novelty: 0.00961765
Score: 0.992
Data Source: STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
Score: 0.991
Data Source: STRINGDB
TOP2B
Tchem
Family: Enzyme
Novelty: 0.00647819
Score: 0.984
Data Source: STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
Score: 0.983
Data Source: Reactome,STRINGDB
VDR
Tclin
Family: NR
Novelty: 0.00058366
Score: 0.962
Data Source: STRINGDB
MYBBP1A
Tbio
Novelty: 0.0261088
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.53

PubMed score by year
PubTator Score  32.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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