Tchem BAZ2B Bromodomain adjacent to zinc finger domain protein 2B

Protein Summary

Description

May play a role in transcriptional regulation interacting with ISWI. This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q9UIF8
• D3DPA8
• Q96EA1
• Q96SQ8
• Q9P252
• Q9Y4N8

Gene Name

• BAZ2B

Ensembl ID

• ENST00000392782
• ENSP00000376533
• ENSG00000123636
• ENST00000392783
• ENSP00000376534

Symbol

• KIAA1476
• WALp4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
trait	0.93
transcription factor binding site profile	0.81
transcription factor perturbation	0.74
cell line	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.73   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.73   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0