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Tchem
BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

Protein Summary
Description
May play a role in transcriptional regulation interacting with ISWI. This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392782
  • ENSP00000376533
  • ENSG00000123636
  • ENST00000392783
  • ENSP00000376534

Symbol
  • KIAA1476
  • WALp4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.93
transcription factor binding site profile
0.81
transcription factor perturbation
0.74
cell line
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (16)
1 – 10 of 16
CHEMBL3774575
chemical structure image
CHEMBL3770277
chemical structure image
CHEMBL3770214
chemical structure image
CHEMBL3415185
chemical structure image
CHEMBL3415184
chemical structure image
CHEMBL3770199
chemical structure image
CHEMBL3739699
chemical structure image
CHEMBL3771216
chemical structure image
CHEMBL3415187
chemical structure image
CHEMBL3415182
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sudden cardiac arrest
1
1
0
1.9
76.4
monocyte count
1
1
1
76.3
birth weight
1
1
1
65.2
neutrophil percentage of leukocytes
1
1
1
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sudden cardiac arrest
0
1.9
76.4
monocyte count
1
76.3
birth weight
1
65.2
neutrophil percentage of leukocytes
1
35.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain adjacent to zinc finger domain 2B
VGNC:10584
470568
Mouse
MGI:2442782
407823
Rat
RGD:1309801
317627
Dog
bromodomain adjacent to zinc finger domain 2B
VGNC:53090
478762
Horse
bromodomain adjacent to zinc finger domain 2B
VGNC:51437
100051120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain adjacent to zinc finger domain 2B
Mouse
Rat
Dog
bromodomain adjacent to zinc finger domain 2B
Horse
bromodomain adjacent to zinc finger domain 2B
Protein Structure (262 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UIF8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 262
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (70)
1 – 10 of 70
HDGFL3
Tbio
Family: Epigenetic
Novelty: 0.14292821
p_int: 0.947286315
p_ni: 0.0027053
p_wrong: 0.050008385
Score: 0.327
Data Source: BioPlex,STRINGDB
INA
Tbio
Novelty: 0.00708581
p_int: 0.786360429
p_ni: 0.130334309
p_wrong: 0.083305262
Score: 0.219
Data Source: BioPlex,STRINGDB
ZNF215
Tdark
Family: TF
Novelty: 0.19814973
Score: 0.673
Data Source: STRINGDB
ZNF214
Tbio
Family: TF
Novelty: 0.15323721
Score: 0.673
Data Source: STRINGDB
MAGI1
Tbio
Family: Enzyme
Novelty: 0.06837323
Score: 0.644
Data Source: STRINGDB
ASRGL1
Tbio
Family: Enzyme
Novelty: 0.02377734
Score: 0.643
Data Source: STRINGDB
CALCOCO2
Tbio
Novelty: 0.01456844
Score: 0.626
Data Source: STRINGDB
SETDB2
Tbio
Family: TF; Epigenetic
Novelty: 0.05560622
Score: 0.619
Data Source: STRINGDB
POLE3
Tbio
Family: Enzyme
Novelty: 0.09657513
Score: 0.595
Data Source: STRINGDB
PGC
Tchem
Family: Enzyme
Novelty: 0.00197056
Score: 0.594
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.61

PubMed score by year
PubTator Score  10.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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