MUTYH
Adenine DNA glycosylase
Protein Summary
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
- ENST00000354383
- ENSP00000346354
- ENSG00000132781
- ENST00000355498
- ENSP00000347685
- ENST00000372098
- ENSP00000361170
- ENST00000372104
- ENSP00000361176
- ENST00000372110
- ENSP00000361182
- ENST00000372115
- ENSP00000361187
- ENST00000448481
- ENSP00000409718
- ENST00000456914
- ENSP00000407590
- MYH
- MYH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
histone modification site profile | 0.89 | ||
disease perturbation | 0.79 | ||
kinase perturbation | 0.76 | ||
cell type or tissue | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 833.21 (req: < 5)
Gene RIFs: 251 (req: <= 3)
Antibodies: 302 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 833.21 (req: >= 5)
Gene RIFs: 251 (req: > 3)
Antibodies: 302 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0