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Tbio
MUTYH
Adenine DNA glycosylase

Protein Summary
Description
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354383
  • ENSP00000346354
  • ENSG00000132781
  • ENST00000355498
  • ENSP00000347685
  • ENST00000372098
  • ENSP00000361170
  • ENST00000372104
  • ENSP00000361176
  • ENST00000372110
  • ENSP00000361182
  • ENST00000372115
  • ENSP00000361187
  • ENST00000448481
  • ENSP00000409718
  • ENST00000456914
  • ENSP00000407590

Symbol
  • MYH
  • MYH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.89
disease perturbation
0.79
kinase perturbation
0.76
cell type or tissue
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.59   (req: < 5)
Gene RIFs: 203   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.59   (req: >= 5)
Gene RIFs: 203   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged purine
Reactome
DNA Repair
Reactome
Defective Base Excision Repair Associated with MUTYH
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged purine
DNA Repair
Defective Base Excision Repair Associated with MUTYH
Gene Ontology Terms (15)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (149)
1 – 10 of 149
MSH2
Tbio
Novelty: 0.00062722
Score: 0.962
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00035132
Score: 0.941
Data Source: Reactome,STRINGDB
OGG1
Tbio
Family: Enzyme
Novelty: 0.00054356
Score: 0.939
Data Source: STRINGDB
MSH6
Tbio
Family: Epigenetic
Novelty: 0.00148002
Score: 0.925
Data Source: STRINGDB
HUS1
Tbio
Novelty: 0.01022325
Score: 0.91
Data Source: STRINGDB
NTHL1
Tbio
Family: Enzyme
Novelty: 0.0107811
Score: 0.891
Data Source: STRINGDB
POLE2
Tbio
Family: Enzyme
Novelty: 0.0524305
Score: 0.85
Data Source: STRINGDB
MLH1
Tbio
Novelty: 0.00040798
Score: 0.842
Data Source: STRINGDB
UNG
Tbio
Family: Enzyme
Novelty: 0.0013114
Score: 0.84
Data Source: STRINGDB
PMS2
Tbio
Family: Enzyme
Novelty: 0.00235398
Score: 0.825
Data Source: STRINGDB
Publication Statistics
PubMed Score  837.59

PubMed score by year
PubTator Score  473.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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