ZNF639
Zinc finger protein 639
Protein Summary
Binds DNA and may function as a transcriptional repressor. This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
- ENST00000326361
- ENSP00000325634
- ENSG00000121864
- ENST00000484866
- ENSP00000418766
- ENST00000496856
- ENSP00000417740
- ENST00000621687
- ENSP00000477626
- ZASC1
- ZASC1
- ANC-2H01
- ANC_2H01
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
histone modification site profile | 0.87 | ||
kinase perturbation | 0.84 | ||
disease perturbation | 0.83 | ||
transcription factor binding site profile | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.7 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 64 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.7 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 64 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0