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Tbio
ZNF639
Zinc finger protein 639

Protein Summary
Description
Binds DNA and may function as a transcriptional repressor. This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326361
  • ENSP00000325634
  • ENSG00000121864
  • ENST00000484866
  • ENSP00000418766
  • ENST00000496856
  • ENSP00000417740
  • ENST00000621687
  • ENSP00000477626

Symbol
  • ZASC1
  • ZASC1
  • ANC-2H01
  • ANC_2H01
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.87
kinase perturbation
0.84
disease perturbation
0.83
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.28   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.28   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (15)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (31)
1 – 10 of 31
ELP6
Tbio
Novelty: 0.01229878
p_int: 0.999999957
p_ni: 1.8e-8
p_wrong: 2.5e-8
Score: 0.534
Data Source: BioPlex,STRINGDB
RASSF8
Tbio
Novelty: 0.09245647
p_int: 0.999999548
p_ni: 4.5e-7
p_wrong: 2e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.999925196
p_ni: 0.000042896
p_wrong: 0.000031908
Score: 0.191
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.946373097
p_ni: 0.000047292
p_wrong: 0.053579611
Score: 0.241
Data Source: BioPlex,STRINGDB
HEXIM1
Tbio
Novelty: 0.0142443
Score: 0.797
Data Source: STRINGDB
CCNT1
Tchem
Novelty: 0.00526848
Score: 0.739
Data Source: STRINGDB
CDK9
Tchem
Family: Kinase
Novelty: 0.00210218
Score: 0.722
Data Source: STRINGDB
PAPSS1
Tbio
Family: Enzyme
Novelty: 0.01784751
Score: 0.66
Data Source: STRINGDB
DUSP3
Tchem
Family: Enzyme
Novelty: 0.00518547
Score: 0.633
Data Source: STRINGDB
ATXN7L1
Tdark
Novelty: 0.43694835
Score: 0.629
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.28

PubMed score by year
PubTator Score  4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer