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Tbio
LCMT1
Leucine carboxyl methyltransferase 1

Protein Summary
Description
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380966
  • ENSP00000370353
  • ENSG00000205629
  • ENST00000399069
  • ENSP00000382021

Symbol
  • LCMT
  • LCMT
  • PPMT1
  • CGI-68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
kinase perturbation
0.93
disease perturbation
0.83
histone modification site profile
0.76
transcription factor binding site profile
0.72


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.81   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.81   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine carboxyl methyltransferase 1
VGNC:5832
467930
Macaque
leucine carboxyl methyltransferase 1
702050
Mouse
MGI:1353593
30949
Rat
RGD:735118
361643
Dog
leucine carboxyl methyltransferase 1
VGNC:42609
608360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine carboxyl methyltransferase 1
Macaque
leucine carboxyl methyltransferase 1
Mouse
Rat
Dog
leucine carboxyl methyltransferase 1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Reactome
G2/M Transition
Reactome
Mitotic G2-G2/M phases
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
G2/M Transition
Mitotic G2-G2/M phases
Protein-Protein Interactions (63)
1 – 10 of 63
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
p_int: 0.96394736
p_ni: 0.036052639
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
PPP4R2
Tbio
Family: Enzyme
Novelty: 0.15136638
p_int: 0.903560376
p_ni: 0.096439624
Score: 0.816
Data Source: BioPlex,STRINGDB
PPP4C
Tbio
Family: Enzyme
Novelty: 0.00705824
p_int: 0.873735571
p_ni: 0.126264429
Score: 0.916
Data Source: BioPlex,STRINGDB
PPP2R2A
Tchem
Family: Enzyme
Novelty: 0.01723628
Score: 0.993
Data Source: STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
Score: 0.97
Data Source: STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
Score: 0.968
Data Source: STRINGDB
PPP2R1B
Tbio
Family: Enzyme
Novelty: 0.03936638
Score: 0.961
Data Source: STRINGDB
PPP2R3B
Tbio
Family: Enzyme
Novelty: 0.02932064
Score: 0.955
Data Source: STRINGDB
PTPA
Tchem
Family: Enzyme
Novelty: 0.00048652
Score: 0.921
Data Source: STRINGDB
PPME1
Tchem
Family: Enzyme
Novelty: 0.01559862
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.81

PubMed score by year
PubTator Score  13.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer