Tbio LCMT1 Leucine carboxyl methyltransferase 1

Protein Summary

Description

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9UIC8
• A6NL89
• A8K770
• Q53FC5
• Q96CI5
• Q9H6I9
• Q9NTG4
• Q9Y378

Gene Name

• LCMT1

Ensembl ID

• ENST00000380966
• ENSP00000370353
• ENSG00000205629
• ENST00000399069
• ENSP00000382021

Symbol

• LCMT
• LCMT
• PPMT1
• CGI-68

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
kinase perturbation	0.93
disease perturbation	0.83
histone modification site profile	0.76
transcription factor binding site profile	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.7   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 205   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.7   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0