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Tbio
CTNNA3
Catenin alpha-3

Protein Summary
Description
May be involved in formation of stretch-resistant cell-cell adhesion complexes. This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433211
  • ENSP00000389714
  • ENSG00000183230

Symbol
  • VR22
  • ARVD13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
disease
0.72
cell type or tissue
0.7
transcription factor
0.66
transcription factor binding site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
7
7
89.9
neutrophil count
2
2
2
73.4
mathematical ability
1
2
2
70.4
mean platelet volume
2
2
2
64.8
wellbeing measurement
3
3
4
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
7
89.9
neutrophil count
2
73.4
mathematical ability
2
70.4
mean platelet volume
2
64.8
wellbeing measurement
4
60.2
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
catenin alpha 3 [Source:HGNC Symbol;Acc:HGNC:2511]
Mouse
MGI:2661445
216033
Cow
catenin alpha 3
VGNC:27800
780777
Chicken
catenin alpha 3
CGNC:2051
423648
C. elegans
179624
Species
Name
OMA
EggNOG
Inparanoid
Macaque
catenin alpha 3 [Source:HGNC Symbol;Acc:HGNC:2511]
Mouse
Cow
catenin alpha 3
Chicken
catenin alpha 3
C. elegans
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UI47-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (45)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Gastric cancer
KEGG
Adherens junction
KEGG
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG
Hippo signaling pathway
KEGG
Endometrial cancer
Name
Explore in Pharos
Explore in Source
Gastric cancer
Adherens junction
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Hippo signaling pathway
Endometrial cancer
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (86)
1 – 10 of 86
CDH3
Tbio
Novelty:  0.00295114
p_int:  0.999999981
p_ni:  6e-9
p_wrong:  1.4e-8
Score:  0.416
Data Source:  BioPlex,STRINGDB
CDH12
Tbio
Novelty:  0.05023568
p_int:  0.999999959
p_ni:  1e-9
p_wrong:  4e-8
Score:  0.363
Data Source:  BioPlex,STRINGDB
CDH1
Tbio
Novelty:  0.00010629
p_int:  0.999999802
p_ni:  4.4e-8
p_wrong:  1.54e-7
Score:  0.908
Data Source:  BioPlex,STRINGDB
APC
Tchem
Novelty:  0.00168376
p_int:  0.999999036
p_ni:  9.64e-7
Score:  0.36
Data Source:  BioPlex,STRINGDB
CDH24
Tbio
Novelty:  0.41415899
p_int:  0.999999025
p_ni:  5.8e-8
p_wrong:  9.17e-7
Score:  0.355
Data Source:  BioPlex,STRINGDB
BLZF1
Tbio
Novelty:  0.04344183
p_int:  0.999997697
p_ni:  0.000002303
Score:  0.185
Data Source:  BioPlex,STRINGDB
CDH10
Tbio
Novelty:  0.06137544
p_int:  0.999996276
p_ni:  9.44e-7
p_wrong:  0.00000278
Score:  0.437
Data Source:  BioPlex,STRINGDB
ARVCF
Tbio
Novelty:  0.03248592
p_int:  0.999989529
p_ni:  0.000010471
Score:  0.375
Data Source:  BioPlex,STRINGDB
PKP4
Tbio
Novelty:  0.03654703
p_int:  0.999989104
p_ni:  0.000010896
Score:  0.433
Data Source:  BioPlex,STRINGDB
CDH4
Tbio
Novelty:  0.01325411
p_int:  0.999877245
p_wrong:  0.000122755
Score:  0.443
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  63.63

PubMed score by year
PubTator Score  33.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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