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Tbio
MRM2
rRNA methyltransferase 2, mitochondrial

Protein Summary
Description
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242257
  • ENSP00000242257
  • ENSG00000122687
  • ENST00000440306
  • ENSP00000392343

Symbol
  • FJH1
  • FTSJ2
  • FJH1
  • FTSJ2
  • HEL97
  • RRMJ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (219)
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999977068
p_ni:  0.00002248
p_wrong:  4.52e-7
Data Source:  BioPlex
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.999963488
p_ni:  0.000036506
p_wrong:  5e-9
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.999961234
p_ni:  0.000037276
p_wrong:  0.00000149
Score:  0.281
Data Source:  BioPlex,STRINGDB
PI15
Tbio
Family:  Enzyme
Novelty:  0.02244161
p_int:  0.999959422
p_ni:  0.000003748
p_wrong:  0.000036831
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999886932
p_ni:  0.000113064
p_wrong:  4e-9
Data Source:  BioPlex
CELA2B
Tdark
Family:  Enzyme
Novelty:  0.43122129
p_int:  0.999862532
p_ni:  0.000137461
p_wrong:  7e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
NIT1
Tbio
Family:  Enzyme
Novelty:  0.00498587
p_int:  0.99983219
p_ni:  0.000167794
p_wrong:  1.6e-8
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.999429212
p_ni:  0.000556904
p_wrong:  0.000013884
Data Source:  BioPlex
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.995977386
p_ni:  0.004022615
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.991073203
p_ni:  0.008926797
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA modification in the mitochondrion
Reactome
rRNA processing
Reactome
rRNA processing in the mitochondrion
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA modification in the mitochondrion
rRNA processing
rRNA processing in the mitochondrion
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
plasminogen activator inhibitor 1 measurement
2
3
0
545
92
self reported educational attainment
2
3
3
91.1
serum albumin measurement
1
2
2
90.3
mathematical ability
2
3
3
85.8
blood protein measurement
1
1
1
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
plasminogen activator inhibitor 1 measurement
0
545
92
self reported educational attainment
3
91.1
serum albumin measurement
2
90.3
mathematical ability
3
85.8
blood protein measurement
1
84.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial rRNA methyltransferase 2
VGNC:10075
463224
Macaque
mitochondrial rRNA methyltransferase 2
698100
Mouse
MGI:1915267
68017
Rat
RGD:1305944
304323
Dog
mitochondrial rRNA methyltransferase 2
VGNC:43367
100684914
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial rRNA methyltransferase 2
Macaque
mitochondrial rRNA methyltransferase 2
Mouse
Rat
Dog
mitochondrial rRNA methyltransferase 2
Publication Statistics
PubMed Score 15.45
PubMed score by year
PubTator Score 5.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title