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Tbio
CPA4
Carboxypeptidase A4

Protein Summary
Description
Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222482
  • ENSP00000222482
  • ENSG00000128510
  • ENST00000445470
  • ENSP00000412947
  • ENST00000647977
  • ENSP00000497118

Symbol
  • CPA3
  • CPA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
small molecule perturbation
0.58
molecular function
0.56
tissue sample
0.51
microRNA
0.44


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.55   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.55   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase A4
VGNC:4318
463727
Macaque
carboxypeptidase A4
702856
Mouse
MGI:1919041
71791
Rat
RGD:1563619
502736
Dog
carboxypeptidase A4
VGNC:39545
482258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase A4
Macaque
carboxypeptidase A4
Mouse
Rat
Dog
carboxypeptidase A4
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UI42-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (71)
1 – 10 of 71
ZIC1
Tbio
Family: TF
Novelty: 0.00491601
p_int: 0.999157201
p_ni: 0.000842799
Data Source: BioPlex
AIRE
Tbio
Family: TF; Epigenetic
Novelty: 0.00158659
p_int: 0.989757993
p_ni: 0.010242007
Data Source: BioPlex
FTH1
Tbio
Novelty: 0.000863
p_int: 0.989033715
p_ni: 0.010965798
p_wrong: 4.88e-7
Data Source: BioPlex
CFAP298
Tbio
Novelty: 0.1550579
p_int: 0.974151159
p_ni: 0.025841285
p_wrong: 0.000007555
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.968718331
p_ni: 0.031281644
p_wrong: 2.5e-8
Data Source: BioPlex
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.967894528
p_ni: 0.03210058
p_wrong: 0.000004892
Data Source: BioPlex
RAB9B
Tbio
Family: Enzyme
Novelty: 0.19952686
p_int: 0.964171657
p_ni: 0.035828245
p_wrong: 9.8e-8
Data Source: BioPlex
UBAC2
Tbio
Novelty: 0.13384376
p_int: 0.960323525
p_ni: 0.039676406
p_wrong: 6.9e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.957657989
p_ni: 0.042342011
Data Source: BioPlex
SLCO6A1
Tbio
Family: Transporter
Novelty: 0.07836028
p_int: 0.940958679
p_ni: 0.059041321
Data Source: BioPlex
Publication Statistics
PubMed Score  72.55

PubMed score by year
PubTator Score  18.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer