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Tbio
SLC24A2
Sodium/potassium/calcium exchanger 2

Protein Summary
Description
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 20 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286344
  • ENSP00000286344
  • ENSG00000155886
  • ENST00000341998
  • ENSP00000344801

Symbol
  • NCKX2
  • NCKX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
microRNA
0.91
trait
0.86
cell line
0.59
biological process
0.57


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.77   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.77   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
53.1
risk-taking behaviour
2
1
2
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
53.1
risk-taking behaviour
2
17.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 24 member 2
VGNC:8929
473181
Macaque
solute carrier family 24 member 2
711896
Mouse
MGI:1923626
76376
Rat
RGD:628650
84550
Dog
solute carrier family 24 member 2
VGNC:46286
481554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 24 member 2
Macaque
solute carrier family 24 member 2
Mouse
Rat
Dog
solute carrier family 24 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UI40-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium/Calcium exchangers
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium/Calcium exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (44)
1 – 10 of 44
SLC6A1
Tclin
Family:  Transporter
Novelty:  0.00165116
Score:  0.741
Data Source:  STRINGDB
TRIM4
Tbio
Family:  Enzyme
Novelty:  0.11398363
Score:  0.689
Data Source:  STRINGDB
HHIP
Tbio
Novelty:  0.00982404
Score:  0.663
Data Source:  STRINGDB
SH3GL2
Tbio
Novelty:  0.0188955
Score:  0.661
Data Source:  STRINGDB
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
Score:  0.652
Data Source:  STRINGDB
GUCA1C
Tdark
Family:  Enzyme
Novelty:  0.25914047
Score:  0.618
Data Source:  STRINGDB
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
Score:  0.614
Data Source:  STRINGDB
KCNIP1
Tbio
Family:  IC
Novelty:  0.01790042
Score:  0.573
Data Source:  STRINGDB
CRKL
Tbio
Novelty:  0.0051181
Score:  0.56
Data Source:  STRINGDB
RCVRN
Tbio
Novelty:  0.00266222
Score:  0.553
Data Source:  STRINGDB
Publication Statistics
PubMed Score  32.77

PubMed score by year
PubTator Score  24.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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