Tbio DACH1 Dachshund homolog 1

Protein Summary

Description

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q9UI36
• A0A087WZP2
• D0FY35
• D0FY36
• O75523
• O75687
• Q5VYY3
• Q5VYY4
• Q96SG3
• Q96SG4
• Q9H524
• Q9UMH4
• Dach1

Gene Name

• DACH1

Ensembl ID

• ENST00000611519
• ENSP00000482493
• ENSG00000276644
• ENST00000613252
• ENSP00000482245
• ENST00000619232
• ENSP00000482797
• ENST00000620444
• ENSP00000481551

Symbol

• DACH
• DACH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.96
transcription factor perturbation	0.94
gene perturbation	0.72
hub protein	0.67
tissue sample	0.65

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Dachshund Homolog 1

DTO Classes

Protein / Transcription Factor / Dachshund Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.3   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.3   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0