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Tclin
SCN11A
Sodium channel protein type 11 subunit alpha

Protein Summary
Description
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302328
  • ENSP00000307599
  • ENSG00000168356
  • ENST00000444237
  • ENSP00000408028
  • ENST00000456224
  • ENSP00000416757

Symbol
  • SCN12A
  • SNS2
  • NaN
  • PN5
  • FEPS3
  • HSAN7
  • SNS-2
  • NAV1.9
  • SCN12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
gene perturbation
0.74
protein domain
0.73
cell type or tissue
0.71
small molecule perturbation
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.69   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.69   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
tetrodotoxin
Rendered image for tetrodotoxin
Protein-Protein Interactions (60)
1 – 10 of 60
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
Score:  0.966
Data Source:  STRINGDB
SCN4B
Tbio
Family:  IC
Novelty:  0.02505113
Score:  0.955
Data Source:  STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
Score:  0.943
Data Source:  STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
Score:  0.94
Data Source:  STRINGDB
ANK1
Tbio
Novelty:  0.00225305
Score:  0.931
Data Source:  STRINGDB
ANK3
Tbio
Novelty:  0.00429246
Score:  0.926
Data Source:  STRINGDB
NFASC
Tbio
Novelty:  0.00545331
Score:  0.918
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.917
Data Source:  STRINGDB
NRCAM
Tbio
Novelty:  0.00443497
Score:  0.913
Data Source:  STRINGDB
SPTBN1
Tbio
Novelty:  0.01490638
Score:  0.902
Data Source:  STRINGDB
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
2
1
0
4.3
84
platelet crit
1
1
1
57.8
platelet count
1
1
1
54.4
metabolic syndrome
1
1
1
15.8
social communication impairment
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
0
4.3
84
platelet crit
1
57.8
platelet count
1
54.4
metabolic syndrome
1
15.8
social communication impairment
1
3.6
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 11
VGNC:12182
460275
Macaque
sodium voltage-gated channel alpha subunit 11
695258
Mouse
MGI:1345149
24046
Rat
RGD:3630
29701
Dog
sodium voltage-gated channel alpha subunit 11
VGNC:45914
485593
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 11
Macaque
sodium voltage-gated channel alpha subunit 11
Mouse
Rat
Dog
sodium voltage-gated channel alpha subunit 11
Publication Statistics
PubMed Score 737.69
PubMed score by year
PubTator Score 252.67
PubTator score by year
Patents
Patents by year