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Tbio
TRMT112
Multifunctional methyltransferase subunit TRM112-like protein

Protein Summary
Description
Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308774
  • ENSP00000309433
  • ENSG00000173113
  • ENST00000544844
  • ENSP00000438349

Symbol
  • TRM112
  • HSPC152
  • HSPC170
  • hTrm112
  • TRMT11-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.87
transcription factor perturbation
0.8
hub protein
0.79
tissue
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (51)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
6
7
97.1
BMI-adjusted waist-hip ratio
6
6
10
97.1
urate measurement
1
4
4
94.5
triglyceride measurement
4
3
4
93.5
high density lipoprotein cholesterol measurement
5
3
5
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
7
97.1
BMI-adjusted waist-hip ratio
10
97.1
urate measurement
4
94.5
triglyceride measurement
4
93.5
high density lipoprotein cholesterol measurement
5
92.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase subunit 11-2
466652
Macaque
tRNA methyltransferase subunit 11-2
717676
Mouse
MGI:1914924
67674
Rat
RGD:1309710
293700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase subunit 11-2
Macaque
tRNA methyltransferase subunit 11-2
Mouse
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UI30-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Eukaryotic Translation Termination
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Biological oxidations
Eukaryotic Translation Termination
Metabolism
Metabolism of RNA
Metabolism of proteins
Protein-Protein Interactions (183)
1 – 10 of 183
TRMT11
Tbio
Family:  Enzyme
Novelty:  0.11506701
p_int:  0.99924663
p_ni:  0.00075337
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
BUD23
Tbio
Family:  Enzyme
Novelty:  0.04803274
p_int:  0.992745098
p_ni:  0.007254902
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
THUMPD3
Tdark
Novelty:  0.23224828
p_int:  0.986220072
p_ni:  0.013779908
p_wrong:  1.9e-8
Score:  0.553
Data Source:  BioPlex,STRINGDB
N6AMT1
Tbio
Family:  Enzyme
Novelty:  0.04804276
Score:  0.999
Data Source:  Reactome,STRINGDB
ALKBH8
Tbio
Novelty:  0.02797162
Score:  0.994
Data Source:  STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
Score:  0.978
Data Source:  Reactome,STRINGDB
TRMT9B
Tbio
Family:  Enzyme
Novelty:  0.26285485
Score:  0.954
Data Source:  STRINGDB
PNO1
Tbio
Novelty:  0.05311566
Score:  0.953
Data Source:  STRINGDB
GSPT1
Tbio
Family:  Enzyme
Novelty:  0.02545195
Score:  0.938
Data Source:  Reactome,STRINGDB
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
Score:  0.933
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  22.44

PubMed score by year
PubTator Score  5.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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