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Tbio
IPO11
Importin-11

Protein Summary
Description
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325324
  • ENSP00000316651
  • ENSG00000086200
  • ENST00000409296
  • ENSP00000386992

Symbol
  • RANBP11
  • RanBP11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor binding site profile
0.76
transcription factor
0.75
virus perturbation
0.72
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
63.6
mean corpuscular volume
1
1
1
46.9
risk-taking behaviour
2
1
2
44.2
mean reticulocyte volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
63.6
mean corpuscular volume
1
46.9
risk-taking behaviour
2
44.2
mean reticulocyte volume
1
42.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
importin 11
VGNC:4047
461850
Macaque
importin 11
694610
Mouse
MGI:2442377
76582
Dog
importin 11
VGNC:49760
478073
Horse
importin 11
VGNC:49366
100050828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
importin 11
Macaque
importin 11
Mouse
Dog
importin 11
Horse
importin 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UI26-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (92)
1 – 10 of 92
SIGLECL1
Tdark
p_int:  0.998948599
p_ni:  0.001051401
Data Source:  BioPlex
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.997581873
p_ni:  0.002418127
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.995765248
p_ni:  0.00423475
p_wrong:  2e-9
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.99573897
p_ni:  0.00426103
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.992193688
p_ni:  0.007806312
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.991837599
p_ni:  0.00816239
p_wrong:  1.2e-8
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.982058885
p_ni:  0.017941115
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.97015249
p_ni:  0.02984751
Score:  0.258
Data Source:  BioPlex,STRINGDB
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.963239628
p_ni:  0.036760372
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.958090121
p_ni:  0.041909879
Data Source:  BioPlex
Publication Statistics
PubMed Score  11.95

PubMed score by year
PubTator Score  9.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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